TY  - JOUR
A1  - Glutsch, Valerie
A1  - Kneitz, Hermann
A1  - Gesierich, Anja
A1  - Goebeler, Matthias
A1  - Haferkamp, Sebastian
A1  - Becker, Jürgen C.
A1  - Ugurel, Selma
A1  - Schilling, Bastian
T1  - Activity of ipilimumab plus nivolumab in avelumab-refractory Merkel cell carcinoma
JF  - Cancer Immunology, Immunotherapy
N2  - Background
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine cutaneous malignancy with poor prognosis. In Europe, approved systemic therapies are limited to the PD-L1 inhibitor avelumab. For avelumab-refractory patients, efficient and safe treatment options are lacking.
Methods
At three different sites in Germany, clinical and molecular data of patients with metastatic MCC being refractory to the PD-L1 inhibitor avelumab and who were later on treated with combined IPI/NIVO were retrospectively collected and evaluated.
Results
Five patients treated at three different academic sites in Germany were enrolled. Three out of five patients investigated for this report responded to combined IPI/NIVO according to RECIST 1.1. Combined immunotherapy was well tolerated without any grade II or III immune-related adverse events. Two out of three responders to IPI/NIVO received platinum-based chemotherapy in between avelumab and combined immunotherapy.
Conclusion
In this small retrospective study, we observed a high response rate and durable responses to subsequent combined immunotherapy with IPI/NIVO in avelumab-refractory metastatic MCC patients. In conclusion, our data suggest a promising activity of second- or third-line PD-1- plus CTLA-4-blockade in patients with anti-PD-L1-refractory MCC.
KW  - ipilimumab
KW  - Merkel cell carcinoma
KW  - resistance
KW  - avelumab
KW  - nivolumab
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-265635
SN  - 14320851
VL  - 70
IS  - 7
ER  - 
TY  - JOUR
A1  - Stolze, Ina
A1  - Trautmann, Axel
A1  - Goebeler, Matthias
A1  - Stoevesandt, Johanna
T1  - Dangerous Leg Cramps: Severe Pustular Exanthema Caused by an Over-the-Counter Drug
JF  - Acta Dermato-Venereologica
N2  - Abstract is missing
KW  - leg cramps
KW  - over-the-counter drugs
KW  - pustular exanthema
KW  - quinine
KW  - allergy
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-171285
VL  - 96
ER  - 
TY  - JOUR
A1  - Schmidt, Enno
A1  - Sticherling, Michael
A1  - Sárdy, Miklós
A1  - Eming, Rüdiger
A1  - Goebeler, Matthias
A1  - Hertl, Michael
A1  - Hofmann, Silke C.
A1  - Hunzelmann, Nicolas
A1  - Kern, Johannes S.
A1  - Kramer, Harald
A1  - Nast, Alexander
A1  - Orzechowski, Hans‐Dieter
A1  - Pfeiffer, Christiane
A1  - Schuster, Volker
A1  - Sitaru, Cassian
A1  - Zidane, Miriam
A1  - Zillikens, Detlef
A1  - Worm, Margitta
T1  - S2k guidelines for the treatment of pemphigus vulgaris/foliaceus and bullous pemphigoid: 2019 update
JF  - JDDG: Journal der Deutschen Dermatologischen Gesellschaft
KW  - pemphigus vulgaris
KW  - pemphigus foliaceus
KW  - S2k guidelines
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-217806
VL  - 18
IS  - 5
SP  - 516
EP  - 526
ER  -