TY  - JOUR
A1  - van de Donk, Niels W. C. J.
A1  - Palumbo, Antonio
A1  - Johnsen, Hans Erik
A1  - Engelhardt, Monika
A1  - Gay, Francesca
A1  - Gregersen, Henrik
A1  - Hajek, Roman
A1  - Kleber, Martina
A1  - Ludwig, Heinz
A1  - Morgan, Gareth
A1  - Musto, Pellegrino
A1  - Plesner, Torben
A1  - Sezer, Orhan
A1  - Terpos, Evangelos
A1  - Waage, Anders
A1  - Zweegman, Sonja
A1  - Einsele, Hermann
A1  - Sonneveld, Pieter
A1  - Lokhorst, Henk M.
T1  - The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the European Myeloma Network
JF  - Haematologica
N2  - Monoclonal gammopathy of undetermined significance is one of the most common pre-malignant disorders. IgG and IgA monoclonal gammopathy of undetermined significance are precursor conditions of multiple myeloma; light-chain monoclonal gammopathy of undetermined significance of light-chain multiple myeloma; and IgM monoclonal gammopathy of undetermined significance of Waldenstrom's macroglobulinemia and other lymphoproliferative disorders. Clonal burden, as determined by bone marrow plasma cell percentage or M-protein level, as well as biological characteristics, including heavy chain isotype and light chain production, are helpful in predicting risk of progression of monoclonal gammopathy of undetermined significance to symptomatic disease. Furthermore, alterations in the bone marrow microenvironment of monoclonal gammopathy of undetermined significance patients result in an increased risk of venous and arterial thrombosis, infections, osteoporosis, and bone fractures. In addition, the small clone may occasionally be responsible for severe organ damage through the production of a monoclonal protein that has autoantibody activity or deposits in tissues. These disorders are rare and often require therapy directed at eradication of the underlying plasma cell or lymphoplasmacytic clone. In this review, we provide an overview of the clinical relevance of monoclonal gammopathy of undetermined significance. We also give general recommendations of how to diagnose and manage patients with monoclonal gammopathy of undetermined significance.
KW  - multiparameter flow-cytometry
KW  - hematopoietic cell transplantation
KW  - smoldering multiple-myeloma
KW  - venous thromboembolic disease
KW  - bone-mineral density
KW  - population-based cohort
KW  - term-follow-up
KW  - marrow plasma cells
KW  - significance MGUS
KW  - malignant transformation
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-116050
SN  - 0390-6078
VL  - 99
IS  - 6
ER  -