TY  - JOUR
A1  - Jockel-Schneider, Yvonne
A1  - Harks, Inga
A1  - Haubitz, Imme
A1  - Fickl, Stefan
A1  - Eigenthaler, Martin
A1  - Schlagenhauf, Ulrich
A1  - Baulmann, Johannes
T1  - Arterial Stiffness and Pulse Wave Reflection Are Increased in Patients Suffering from Severe Periodontitis
JF  - PLOS ONE
N2  - Aim: This single blind cross-sectional study compared the vascular health of subjects suffering from severe chronic periodontitis, severe aggressive periodontitis and periodontal healthy controls by evaluating pulse wave velocity (PWV), augmentation index (AIx) and pulse pressure amplification (PPA).
Material and Methods: In a total of 158 subjects, 92 suffering from severe periodontitis and 66 matched periodontal healthy controls, PWV, AIx, central and peripheral blood pressure were recorded using an oscillometric device (Arteriograph).
Results: Subjects suffering from severe chronic or aggressive periodontitis exhibited significantly higher PWV (p = 0.00004), higher AIx (p = 0.0049) and lower PPA (p = 0.028) than matched periodontal healthy controls.
Conclusions: The results of this study confirm the association between periodontal inflammation and increased cardiovascular risk shown by impaired vascular health in case of severe periodontitis. As impaired vascular health is a common finding in patients suffering from severe periodontal disease a concomitant routine cardiovascular evaluation may be advised.
KW  - periodontal diseases
KW  - diagnostic medicine
KW  - teeth
KW  - stiffness
KW  - reflection
KW  - periodontitis
KW  - blood pressure
KW  - hypertension
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-119459
SN  - 1932-6203
VL  - 9
IS  - 8
ER  - 
TY  - JOUR
A1  - Matern, Johannes
A1  - Koch, Raphael
A1  - Petersmann, Astrid
A1  - Kocher, Thomas
A1  - Eickholz, Peter
A1  - Lorenz, Katrin
A1  - Kim, Ti‐Sun
A1  - Meyle, Jörg
A1  - Kaner, Doğan
A1  - Schlagenhauf, Ulrich
A1  - Gravemeier, Martina
A1  - Harks, Inga
A1  - Ehmke, Benjamin
T1  - Effect of periodontal therapy on adipokine biomarkers in overweight
JF  - Journal of Clinical Periodontology
N2  - Aim
The aim of this study was to evaluate the effect of non‐surgical periodontal therapy on circulating levels of the systemic inflammation‐associated biomarkers orosomucoid (ORM), high‐sensitivity C‐reactive protein (hsCRP), chemerin, and retinol‐binding protein 4 (RBP4) in overweight or normal‐weight patients with periodontitis at 27.5 months after therapy.

Materials and methods
This exploratory subanalysis includes patients from the ABPARO‐trial (ClinicalTrials.gov NCT00707369). The per‐protocol collective provided untreated periodontitis patients with high (≥28 kg/m\(^{2}\)) or moderate (21–24 kg/m\(^{2}\)) BMI. Out of the per‐protocol collective, 80 patients were randomly selected and stratified for BMI group, sex, and treatment group (antibiotics/placebo), resulting in 40 overweight and normal‐weight patients. Patients received non‐surgical periodontal therapy and maintenance at 3‐month intervals. Plasma samples from baseline and 27.5 months following initial treatment were used to measure the concentrations of ORM, hsCRP, chemerin, and RBP4.

Results
At the 27.5‐month examination, ORM and hsCRP decreased noticeably in the overweight group (ORM: p = .001, hsCRP: p = .004) and normal‐weight patients (ORM: p = .007, hsCRP: p < .001). Chemerin decreased in the overweight group (p = .048), and RBP4 concentrations remained stable.

Conclusion
Non‐surgical periodontal therapy reduced systemically elevated inflammation‐associated biomarkers in periodontitis patients. These improvements were more pronounced in overweight patients than in normal‐weight patients.
KW  - chemerin
KW  - orosomucoid
KW  - overweight
KW  - periodontitis
KW  - retinol‐binding protein 4
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-215546
VL  - 47
IS  - 7
SP  - 842
EP  - 850
ER  -