TY  - RPRT
A1  - Lütticken, Claudia
A1  - Wegenka, Ursula M.
A1  - Yuan, Juping
A1  - Buschmann, Jan
A1  - Schindler, Chris
A1  - Ziemiecki, Andrew
A1  - Harpur, Alisa G.
A1  - Wilks, Andrew F.
A1  - Yasukawa, Kiyoshi
A1  - Taga, Tetsuya
A1  - Kishimoto, Tadamitsu
A1  - Barbieri, Giovanna
A1  - Sendtner, Michael
A1  - Pellegrini, Sandra
A1  - Heinrich, Peter C.
A1  - Horn, Friedemann
T1  - Association of transcription factor APRF and protein kinase JAK1 with the IL-6 signal transducer gp130
N2  - Interleukin-6, leukemia inhibitory factor, oncostatin M. Interleukin-11, and cilialy neurotrophic factor bind to receptor complexes that share the signal transducer gp130. Upon binding, the ligands rapidly activate DNA binding of acute-phase response factor (APRF), a protein antigenicaly relaled to the p91 subunit of the interferon-stimulated gene factor-(ISGF-3a). These cytokines caused tyrosine phosphorylation of APRF and ISGF-3a p91. Protein kinases of the Jak family were also rapidly tyrosine phosphorylated, and both APRF and Jak1 associated with gp130. These data indicate that Jak family protein kinases may participate in IL-6 signaling and that APRF may be activated in a complex with gp130.
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42577
ER  -