TY  - THES
A1  - Kieser, Stephanie Beatrix
T1  - Effekt eines 6-monatigen Trainings auf die körperliche Leistungsfähigkeit von Jugendlichen und jungen Erwachsenen mit Mukoviszidose
T1  - Effect of six months of training  of  youth and young adults with cystic fibrosis on physical activity
N2  - Körperliche Aktivität ist ein wichtiges Element im Leben von Patienten mit Cystischer Fibrose. Die körperliche Fitness gilt zur Zeit als einer der besten Prädiktoren für die Langzeit-Mortalität bei Patienten mit CF. Bisherige Studien führten ausschließlich überwachtes Training durch. Ziel dieser Arbeit war es zu überprüfen, ob ein unüberwachtes regelmäßiges körperliches Heimtraining bei Mukoviszidosepatienten über 6 Monate durchführbar ist und eine Verbesserung der körperlichen Leistungsfähigkeit ermöglicht. Es wurden 48 Patienten in Trainingsgruppe (n=23) und Kontrollgruppe (n=25) randomisiert. Die Untersuchungen ergaben im Verlauf eine signifikante Verbesserung der maximalen Sauerstoffaufnahme (VO2 max;p=0.0017) und der maximalen Leistungsfähigkeit (W:p=0.0293) bei der Trainingsgruppe im Vergleich zur Kontrollgruppe. Es wurde nachgewiesen, dass unüberwachtes körperliches Training bei CF-Patienten einen Leistungszuwachs bringt und damit Konsequenzen für ihre Lebensqualität und Lebenserwartung hat.
N2  - Physical activity is an important element in the life of patients with cystic fibrosis. At the moment physical fitness is considered as one of the best predicts for the longtime-mortality with Cf patients. Until now studies only practiced supervised training. The aim of the new thesis was to test wether a regular physical training at home of patients with cystic fibrosis for more than 6 months without supervision is practicable and makes an improvement of the physical efficiency possible. 48 patients were randomised in a training group (n=23) and a control group (n=25). The results of the investigations during this period showed a significant improvement of the maximum oxygenation (VO2 max:p=0.0017) and the maximal aerobic capacity (:p=0.0293) with the training group in comparision with the control group. It was proved that non-supervised physical training of Cf patients accomplishes a growth of efficiency and thus has consequences for the quality and expectation of life.
KW  - Mukoviszidose
KW  - Heimtraining
KW  - Körperliche Leistungsfähigkeit
KW  - cystic fibrosis
KW  - physical acitivity
KW  - hometraining
Y1  - 2008
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-26530
ER  - 
TY  - JOUR
A1  - Hebestreit, Helge
A1  - Schmid, Kerstin
A1  - Kieser, Stephanie
A1  - Junge, Sibylle
A1  - Ballmann, Manfred
A1  - Roth, Kristina
A1  - Hebestreit, Alexandra
A1  - Schenk, Thomas
A1  - Schindler, Christian
A1  - Posselt, Hans-Georg
A1  - Kriemler, Susi
T1  - Quality of life is associated with physical activity and fitness in cystic fibrosis
N2  - Background

Health-related and disease-specific quality of life (HRQoL) has been increasingly valued as relevant clinical parameter in cystic fibrosis (CF) clinical care and clinical trials. HRQoL measures should assess – among other domains – daily functioning from a patient’s perspective. However, validation studies for the most frequently used HRQoL questionnaire in CF, the Cystic Fibrosis Questionnaire (CFQ), have not included measures of physical activity or fitness. The objective of this study was, therefore, to determine the cross-sectional and longitudinal relationships between HRQoL, physical activity and fitness in patients with CF.

Methods

Baseline (n = 76) and 6-month follow-up data (n = 70) from patients with CF (age ≥12 years, FEV1 ≥35%) were analysed. Patients participated in two multi-centre exercise intervention studies with identical assessment methodology. Outcome variables included HRQoL (German revised multi-dimensional disease-specific CFQ (CFQ-R)), body composition, pulmonary function, physical activity, short-term muscle power, and aerobic fitness by peak oxygen uptake and aerobic power.

Results

Peak oxygen uptake was positively related to 7 of 13 HRQoL scales cross-sectionally (r = 0.30-0.46). Muscle power (r = 0.25-0.32) and peak aerobic power (r = 0.24-0.35) were positively related to 4 scales each, and reported physical activity to 1 scale (r = 0.29). Changes in HRQoL-scores were directly and significantly related to changes in reported activity (r = 0.35-0.39), peak aerobic power (r = 0.31-0.34), and peak oxygen uptake (r = 0.26-0.37) in 3 scales each. Established associates of HRQoL such as FEV1 or body mass index correlated positively with fewer scales (all 0.24 < r < 0.55).

Conclusions

HRQoL was associated with physical fitness, especially aerobic fitness, and to a lesser extent with reported physical activity. These findings underline the importance of physical fitness for HRQoL in CF and provide an additional rationale for exercise testing in this population.
KW  - Exercise testing
KW  - Oxygen uptake
KW  - Longitudinal analysis
KW  - Accelerometry
KW  - Questionnaire
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-110508
ER  -