TY  - CHAP
A1  - Werner, Rudolf
A1  - Chen, Xinyu
A1  - Lapa, Constantin
A1  - Robinson, Simon
A1  - Higuchi, Takahiro
T1  - Intracellular behavior of the novel sympathetic nerve agent \(^{18}\)F-LMI1195
T2  - Journal of Nuclear Cardiology
N2  - No abstract available.
KW  - Herz
KW  - PET
KW  - sympathetic nerve
KW  - autonomic nervous system
KW  - 18F-LMI1195
KW  - positron emission tomography
KW  - heart
KW  - cardiac
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-161137
SN  - 1071-3581
N1  - This is a post-peer-review, pre-copyedit version of an article published in J Nucl Cardiol. ISSN: 1071-3581. Supplement (2017) Aug;24;4: 1461-1496. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12350-017-0984-y
VL  - 24
IS  - 4 Supplement (2017) Aug
ER  - 
TY  - JOUR
A1  - Lapa, Constantin
A1  - Arias-Loza, Paula
A1  - Hayakawa, Nobuyuki
A1  - Wakabayashi, Hiroshi
A1  - Werner, Rudolf A.
A1  - Chen, Xinyu
A1  - Shinaji, Tetsuya
A1  - Herrmann, Ken
A1  - Pelzer, Theo
A1  - Higuchi, Takahiro
T1  - Whitening and impaired glucose utilization of brown adipose tissue in a rat model of type 2 diabetes mellitus
JF  - Scientific Reports
N2  - Brown adipose tissue (BAT) is an attractive therapeutic target to combat diabetes and obesity due to its ability to increase glucose expenditure. In a genetic rat model (ZDF fa/fa) of type-2 diabetes and obesity, we aimed to investigate glucose utilization of BAT by \(^{18}\)F-FDG PET imaging. Male Zucker diabetic fatty (ZDF) and Male Zucker lean (ZL) control rats were studied at 13 weeks. Three weeks prior to imaging, ZDF rats were randomized into a no-restriction (ZDF-ND) and a mild calorie restriction (ZDF-CR) group. Dynamic \(^{18}\)F-FDG PET using a dedicated small animal PET system was performed under hyperinsulinemic-euglycemic clamp. \(^{18}\)F-FDG PET identified intense inter-scapular BAT glucose uptake in all ZL control rats, while no focally increased \(^{18}\)F-FDG uptake was detected in all ZDF-ND rats. Mild but significant improved BAT tracer uptake was identified after calorie restriction in diabetic rats (ZDF-CR). The weight of BAT tissue and fat deposits were significantly increased in ZDF-CR and ZDF-ND rats as compared to ZL controls, while UCP-1 and mitochondrial concentrations were significantly decreased. Whitening and severely impaired insulin-stimulated glucose uptake in BAT was confirmed in a rat model of type-2 diabetes. Additionally, calorie restriction partially restored the impaired BAT glucose uptake.
KW  - molecular medicine
KW  - endocrinology
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-159066
VL  - 7
ER  -