TY  - JOUR
A1  - Schmitt, Elke
A1  - Meybohm, Patrick
A1  - Neef, Vanessa
A1  - Baumgarten, Peter
A1  - Bayer, Alexandra
A1  - Choorapoikayil, Suma
A1  - Friederich, Patrick
A1  - Friedrich, Jens
A1  - Geisen, Christof
A1  - Güresir, Erdem
A1  - Grünewald, Matthias
A1  - Gutjahr, Martin
A1  - Helmer, Philipp
A1  - Herrmann, Eva
A1  - Müller, Markus
A1  - Narita, Diana
A1  - Raadts, Ansgar
A1  - Schwendner, Klaus
A1  - Seifried, Erhard
A1  - Stark, Patrick
A1  - Steinbicker, Andrea U.
A1  - Thoma, Josef
A1  - Velten, Markus
A1  - Weigt, Henry
A1  - Wiesenack, Christoph
A1  - Wittmann, Maria
A1  - Zacharowski, Kai
A1  - Piekarski, Florian
T1  - Preoperative anaemia and red blood cell transfusion in patients with aneurysmal subarachnoid and intracerebral haemorrhage - a multicentre subanalysis of the German PBM Network Registry
JF  - Acta Neurochirurgica
N2  - Purpose
Anaemia is common in patients presenting with aneurysmal subarachnoid (aSAH) and intracerebral haemorrhage (ICH). In surgical patients, anaemia was identified as an idenpendent risk factor for postoperative mortality, prolonged hospital length of stay (LOS) and increased risk of red blood cell (RBC) transfusion. This multicentre cohort observation study describes the incidence and effects of preoperative anaemia in this critical patient collective for a 10-year period.

Methods
This multicentre observational study included adult in-hospital surgical patients diagnosed with aSAH or ICH of 21 German hospitals (discharged from 1 January 2010 to 30 September 2020). Descriptive, univariate and multivariate analyses were performed to investigate the incidence and association of preoperative anaemia with RBC transfusion, in-hospital mortality and postoperative complications in patients with aSAH and ICH.

Results
A total of n = 9081 patients were analysed (aSAH n = 5008; ICH n = 4073). Preoperative anaemia was present at 28.3% in aSAH and 40.9% in ICH. RBC transfusion rates were 29.9% in aSAH and 29.3% in ICH. Multivariate analysis revealed that preoperative anaemia is associated with a higher risk for RBC transfusion (OR = 3.25 in aSAH, OR = 4.16 in ICH, p < 0.001), for in-hospital mortality (OR = 1.48 in aSAH, OR = 1.53 in ICH, p < 0.001) and for several postoperative complications.

Conclusions
Preoperative anaemia is associated with increased RBC transfusion rates, in-hospital mortality and postoperative complications in patients with aSAH and ICH.
KW  - aneurysmal subarachnoid haemorrhage
KW  - intracerebral haemorrhage
KW  - anaemia
KW  - red blood cell transfusion
KW  - patient blood management
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-346754
VL  - 164
ER  - 
TY  - JOUR
A1  - Fischer, Dania
A1  - Thies, Fabian
A1  - Awad, Omar
A1  - Brat, Camilla
A1  - Meybohm, Patrick
A1  - Baer, Patrick C.
A1  - Müller, Markus M.
A1  - Urbschat, Anja
A1  - Maier, Thorsten J.
A1  - Zacharowski, Kai
A1  - Roos, Jessica
T1  - Red blood cell-derived microparticles exert no cancer promoting effects on colorectal cancer cells in vitro
JF  - International Journal of Molecular Sciences
N2  - The biomedical consequences of allogeneic blood transfusions and the possible pathomechanisms of transfusion-related morbidity and mortality are still not entirely understood. In retrospective studies, allogeneic transfusion was associated with increased rates of cancer recurrence, metastasis and death in patients with colorectal cancer. However, correlation does not imply causation. The purpose of this study was to elucidate this empirical observation further in order to address insecurity among patients and clinicians. We focused on the in vitro effect of microparticles derived from red blood cell units (RMPs). We incubated different colon carcinoma cells with RMPs and analyzed their effects on growth, invasion, migration and tumor marker expression. Furthermore, effects on Wnt, Akt and ERK signaling were explored. Our results show RMPs do not seem to affect functional and phenotypic characteristics of different colon carcinoma cells and did not induce or inhibit Wnt, Akt or ERK signaling, albeit in cell culture models lacking tumor microenvironment. Allogeneic blood transfusions are associated with poor prognosis, but RMPs do not seem to convey tumor-enhancing effects. Most likely, the circumstances that necessitate the transfusion, such as preoperative anemia, tumor stage, perioperative blood loss and extension of surgery, take center stage.
KW  - transfusion
KW  - red blood cells
KW  - microparticles
KW  - colorectal carcinoma
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-286018
SN  - 1422-0067
VL  - 23
IS  - 16
ER  -