TY  - JOUR
A1  - Weiße, Sebastian
A1  - Heddergott, Niko
A1  - Heydt, Matthias
A1  - Pflästerer, Daniel
A1  - Maier, Timo
A1  - Haraszti, Tamas
A1  - Grunze, Michael
A1  - Engstler, Markus
A1  - Rosenhahn, Axel
T1  - A Quantitative 3D Motility Analysis of Trypanosoma brucei by Use of Digital In-line Holographic Microscopy
JF  - PLoS One
N2  - We present a quantitative 3D analysis of the motility of the blood parasite Trypanosoma brucei. Digital in-line holographic microscopy has been used to track single cells with high temporal and spatial accuracy to obtain quantitative data on their behavior. Comparing bloodstream form and insect form trypanosomes as well as mutant and wildtype cells under varying external conditions we were able to derive a general two-state-run-and-tumble-model for trypanosome motility. Differences in the motility of distinct strains indicate that adaption of the trypanosomes to their natural environments involves a change in their mode of swimming.
KW  - african trypanosomes
KW  - actin cortex
KW  - flagellum
KW  - tracking
KW  - surface
KW  - models
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-130666
VL  - 7
IS  - 5
ER  -