TY  - JOUR
A1  - Masu, Yasuo
A1  - Wolf, Eckhard
A1  - Holtmann, Bettina
A1  - Sendtner, Michael
A1  - Brem, Gottfried
A1  - Thoenen, Hans
T1  - Disruption of the CNTF gene results in motor neuron degeneration
N2  - CNTF is a cytosolic molecule expressed postnatally in myelinating Schwann cells and in a subpopulation of astrocytes. Although CNTF administration prevents lesion-mediated and genetically determined motor neuron degeneration, its physiological function remained elusive. Here it is reported that abolition of CNTF gene expression by homologous recombination results in a progressive atrophy and loss of motor neurons in adult mice, which is functionally reflected by a small but significant reduction in muscle strength.
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33038
ER  -