TY  - JOUR
A1  - Kunath, Frank
A1  - Krause, Steffen F.
A1  - Wullich, Bernd
A1  - Goebell, Peter J.
A1  - Engehausen, Dirk G.
A1  - Burger, Maximilian
A1  - Meerpohl, Joerg J.
A1  - Keck, Bastian
T1  - Bladder cancer - the neglected tumor: a descriptive analysis of publications referenced in MEDLINE and data from the register clinicaltrials.gov
JF  - BMC Urology
N2  - Background: Uro-oncological neoplasms have both a high incidence and mortality rate and are therefore a major public health problem. The aim of this study was to evaluate research activity in uro-oncology over the last decade. 
Methods: We searched MEDLINE and ClinicalTrials.gov systematically for studies on prostatic, urinary bladder, kidney, and testicular neoplasms. The increase in newly published reports per year was analyzed using linear regression. The results are presented with 95% confidence intervals, and a p value <0.05 was considered statistically significant. 
Results: The number of new publications per year increased significantly for prostatic, kidney and urinary bladder neoplasms (all <0.0001). We identified 1,885 randomized controlled trials (RCTs); also for RCTs, the number of newly published reports increased significantly for prostatic (p = 0.001) and kidney cancer (p = 0.005), but not for bladder (p = 0.09) or testicular (p = 0.44) neoplasms. We identified 3,114 registered uro-oncological studies in ClinicalTrials.gov. However, 85% of these studies are focusing on prostatic (45%) and kidney neoplasms (40%), whereas only 11% were registered for bladder cancers. 
Conclusions: While the number of publications on uro-oncologic research rises yearly for prostatic and kidney neoplasms, urothelial carcinomas of the bladder seem to be neglected despite their important clinical role. Clinical research on neoplasms of the urothelial bladder must be explicitly addressed and supported.
KW  - update
KW  - kidney neoplasms
KW  - prostatic neoplasms
KW  - randomized controlled trial
KW  - testicular neoplasms
KW  - surgery
KW  - journals
KW  - EAU guidelines
KW  - radical cystectomy
KW  - urinary bladder neoplasms
KW  - controlled clinical-trials
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-122133
VL  - 13
IS  - 56
ER  - 
TY  - JOUR
A1  - Holzmann-Littig, Christopher
A1  - Frank, Tamara
A1  - Schmaderer, Christoph
A1  - Braunisch, Matthias C.
A1  - Renders, Lutz
A1  - Kranke, Peter
A1  - Popp, Maria
A1  - Seeber, Christian
A1  - Fichtner, Falk
A1  - Littig, Bianca
A1  - Carbajo-Lozoya, Javier
A1  - Meerpohl, Joerg J.
A1  - Haller, Bernhard
A1  - Allwang, Christine
T1  - COVID-19 Vaccines: Fear of side effects among German health care workers
JF  - Vaccines
N2  - (1) Background: Health care workers (HCWs) play a key role in increasing anti-COVID vaccination rates. Fear of potential side effects is one of the main reasons for vaccine hesitancy. We investigated which side effects are of concern to HCWs and how these are associated with vaccine hesitancy. (2) Methods: Data were collected in an online survey in February 2021 among HCWs from across Germany with 4500 included participants. Free-text comments on previously experienced vaccination side effects, and fear of short- and long-term side effects of the COVID-19 vaccination were categorized and analyzed. (3) Results: Most feared short-term side effects were vaccination reactions, allergic reactions, and limitations in daily life. Most feared long-term side effects were (auto-) immune reactions, neurological side effects, and currently unknown long-term consequences. Concerns about serious vaccination side effects were associated with vaccination refusal. There was a clear association between refusal of COVID-19 vaccination in one's personal environment and fear of side effects. (4) Conclusions: Transparent information about vaccine side effects is needed, especially for HCW. Especially when the participants' acquaintances advised against vaccination, they were significantly more likely to fear side effects. Thus, further education of HCW is necessary to achieve good information transfer in clusters as well.
KW  - COVID-19
KW  - vaccine hesitancy
KW  - health care workers
KW  - side-effects
KW  - fears
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-270561
SN  - 2076-393X
VL  - 10
IS  - 5
ER  -