TY  - JOUR
A1  - Holzapfel, Boris Michael
A1  - Chhaya, Mohit Prashant
A1  - Melchels, Ferry Petrus Wilhelmus
A1  - Holzapfel, Nina Pauline
A1  - Prodinger, Peter Michael
A1  - von Eisenhart-Rothe, Rüdiger
A1  - Griensven, Martijn van
A1  - Schantz, Jan-Thorsten
A1  - Rudert, Maximilian
A1  - Hutmacher, Dietmar Werner
T1  - Can Bone Tissue Engineering Contribute to Therapy Concepts after Resection of Musculoskeletal Sarcoma?
JF  - Sarcoma
N2  - Resection of musculoskeletal sarcoma can result in large bone defects where regeneration is needed in a quantity far beyond the normal potential of self-healing. In many cases, these defects exhibit a limited intrinsic regenerative potential due to an adjuvant therapeutic regimen, seroma, or infection. Therefore, reconstruction of these defects is still one of the most demanding procedures in orthopaedic surgery. The constraints of common treatment strategies have triggered a need for new therapeutic concepts to design and engineer unparalleled structural and functioning bone grafts. To satisfy the need for long-term repair and good clinical outcome, a paradigm shift is needed from methods to replace tissues with inert medical devices to more biological approaches that focus on the repair and reconstruction of tissue structure and function. It is within this context that the field of bone tissue engineering can offer solutions to be implemented into surgical therapy concepts after resection of bone and soft tissue sarcoma. In this paper we will discuss the implementation of tissue engineering concepts into the clinical field of orthopaedic oncology.
KW  - musculoskeletal sarcoma
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-132465
VL  - 2013
IS  - Article ID 153640
ER  -