TY  - JOUR
A1  - Neumann, Yvonne
A1  - Ohlsen, Knut
A1  - Donat, Stefanie
A1  - Engelmann, Susanne
A1  - Kusch, Harald
A1  - Albrecht, Dirk
A1  - Cartron, Michael
A1  - Hurd, Alexander
A1  - Foster, Simon J.
T1  - The effect of skin fatty acids on Staphylococcus aureus
JF  - Archives of Microbiology
N2  - Staphylococcus aureus is a commensal of the human nose and skin. Human skin fatty acids, in particular cis-6-hexadecenoic acid (C-6-H), have high antistaphylococcal activity and can inhibit virulence determinant production. Here, we show that sub-MIC levels of C-6-H result in induction of increased resistance. The mechanism(s) of C-6-H activity was investigated by combined transcriptome and proteome analyses. Proteome analysis demonstrated a pleiotropic effect of C-6-H on virulence determinant production. In response to C-6-H, transcriptomics revealed altered expression of over 500 genes, involved in many aspects of virulence and cellular physiology. The expression of toxins (hla, hlb, hlgBC) was reduced, whereas that of host defence evasion components (cap, sspAB, katA) was increased. In particular, members of the SaeRS regulon had highly reduced expression, and the use of specific mutants revealed that the effect on toxin production is likely mediated via SaeRS
KW  - S. aureus
KW  - skin fatty acid
KW  - C-6-H
KW  - resistance
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-121657
VL  - 197
ER  -