TY  - JOUR
A1  - Ott, M.
A1  - Schmoll, T.
A1  - Goebel, W.
A1  - Van Die, I.
A1  - Hacker, Jörg
T1  - Comparison of the genetic determinant coding for the S-fimbrial adhesin (sfa) of Escherichia coli to other chromosomally encoded fimbrial determinants
N2  - DNA probes specific for different regions of the S-fimbrial adhesin (sja) determinant were constructed and hybridized with DNA sequences coding for P (F8 and F13), mannose-sensitive hemagglutinating type 1 (FlA), and FlC fimbriae. While the sfa and F1C DNA determinants exhibited homology along their entire lengths, the P-fimbrial and type 1-fimbrial determinants exhibited homology to regions of the sfa duster responsible for the control of transcription and, to a minor extent, to regions coding for proteins involved in biogenesis and/or adhesion of the fimbriae and for the N-terminal part of the fimbrillin subunit.
KW  - Infektionsbiologie
Y1  - 1987
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59499
ER  - 
TY  - JOUR
A1  - Hacker, Jörg
A1  - Bender, L.
A1  - Ott, M.
A1  - Wingeder, J.
A1  - Lund, B.
A1  - Marre, R.
A1  - Goebel, W.
T1  - Deletions of chromosomal regions coding for fimbriae and hemolysins occur in vivo and in vitro in various extraintestinal Escherichia coli isolates
N2  - No abstract available
KW  - Infektionsbiologie
KW  - P-fimbriae
KW  - hemolysin
KW  - genomic deletions
KW  - extraintestinal E. coli
KW  - virulence modulation
Y1  - 1990
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59608
ER  - 
TY  - JOUR
A1  - Hacker, Jörg
A1  - Ott, M.
A1  - Schmidt, G.
A1  - Hull, R.
A1  - Goebel, W.
T1  - Molecular cloning of the F8 fimbrial antigen from Escherichia coli
N2  - The genetic determinant coding for the Pspecific F8 fimbriae was cloned from · the chromosome of the Escherichia coli wild-type strain 2980 (018: K5: H5: FlC, F8). The F8 determinant was further subcloned into the Pstl site of pBR322 and a restriction map was established. In a Southern hybridization experiment identity between the chromosomally encoded F8 determinant of 2980 and its cloned Counterpart was demonstrated. The cloned F8 fimbriäe and those of the wild type strain consist of a protein subunit of nearly 20 kDa. F8 fimbriated strains were agglutinated by an F8 polyclonal antiserum, caused mannose-resistant hemagglutination and attached to human uroepi thellal cells. The cloned F8 determinant was weil expressed in a variety of host strains.
KW  - Infektionsbiologie
KW  - Escherichia coli
KW  - antigen
KW  - F8 fimbriae
KW  - gene cloning
Y1  - 1986
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59391
ER  -