TY  - JOUR
A1  - Steigerwald, Frank
A1  - Timmermann, Lars
A1  - Kühn, Andrea
A1  - Schnitzler, Alfons
A1  - Reich, Martin M.
A1  - Kirsch, Anna Dalal
A1  - Barbe, Michael Thomas
A1  - Visser-Vandewalle, Veerle
A1  - Hübl, Julius
A1  - van Riesen, Christoph
A1  - Groiss, Stefan Jun
A1  - Moldovan, Alexia-Sabine
A1  - Lin, Sherry
A1  - Carcieri, Stephen
A1  - Manola, Ljubomir
A1  - Volkmann, Jens
T1  - Pulse duration settings in subthalamic stimulation for Parkinson's disease
JF  - Movement Disorders
N2  - Background
Stimulation parameters in deep brain stimulation (DBS) of the subthalamic nucleus for Parkinson's disease (PD) are rarely tested in double-blind conditions. Evidence-based recommendations on optimal stimulator settings are needed. Results from the CUSTOM-DBS study are reported, comparing 2 pulse durations.

Methods
A total of 15 patients were programmed using a pulse width of 30 µs (test) or 60 µs (control). Efficacy and side-effect thresholds and unified PD rating scale (UPDRS) III were measured in meds-off (primary outcome). The therapeutic window was the difference between patients’ efficacy and side effect thresholds.

Results
The therapeutic window was significantly larger at 30 µs than 60 µs (P = ·0009) and the efficacy (UPDRS III score) was noninferior (P = .00008).

Interpretation
Subthalamic neurostimulation at 30 µs versus 60 µs pulse width is equally effective on PD motor signs, is more energy efficient, and has less likelihood of stimulation-related side effects. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
KW  - deep brain stimulation
KW  - Parkinson's disease;
KW  - pulse width
KW  - stimulation parameters
KW  - subthalamic
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-239402
VL  - 33
ER  -