TY  - JOUR
A1  - Huang, Guozheng
A1  - Schramm, Simon
A1  - Heilmann, Jörg
A1  - Biedermann, David
A1  - Kren, Vladimír
A1  - Decker, Michael
T1  - Unconventional application of the Mitsunobu reaction: Selective flavonolignan dehydration yielding hydnocarpins
JF  - Beilstein Journal of Organic Chemistry
N2  - Various Mitsunobu conditions were investigated for a series of flavonolignans (silybin A, silybin B, isosilybin A, and silychristin A) to achieve either selective esterification in position C-23 or dehydration in a one-pot reaction yielding the biologically important enantiomers of hydnocarpin D, hydnocarpin and isohydnocarpin, respectively. This represents the only one-pot semi-synthetic method to access these flavonolignans in high yields.
KW  - Mitsunobu
KW  - dehydration
KW  - flavonoid
KW  - hydnocarpin
KW  - silybin
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-160986
VL  - 12
ER  -