TY  - JOUR
A1  - Feuerstein, G.
A1  - Leader, P.
A1  - Sirén, Anna-Leena
A1  - Braquet, P.
T1  - Protective effect of PAF-acether antagonist, BN 52021, in trichothecen toxicosis
N2  - Trichothecenes are mycotoxins which produce Iethai toxicosis in humans and animals, yet no adequate therapeutic regimen has been developed. This study provides evidence that the selective platelet activating factor (PAF) antagonist, BN 52021 (5-15 mg/kg i.v.) can prolong the survival of conscious rats exposed to a highly Iethai T -2 toxicosis. These data also suggest that P AF is an important mediator of this unique toxicosis.
KW  - Neurobiologie
KW  - T-2 toxin
KW  - mycotoxin
KW  - PAF-acether
KW  - BN 52021
KW  - rat
Y1  - 1987
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63244
ER  -