TY  - JOUR
A1  - Hallenbeck, JM
A1  - Dutka, AJ
A1  - Kochanek, PM
A1  - Sirén, Anna-Leena
A1  - Pezeskpour, GH
A1  - Feuerstein, G.
T1  - Stroke risk factors prepare rat brainstem tissues for a modified localized Shwartzman reaction
N2  - Stroke risk factors such as hypertension, diabetes, advanced age, and genetic predisposition to stroke were demonstrated to prepare rat brainstem tissues for a modified local Shwartzman reaction. A single intracisternal injection of endotoxin provoked the reaction, and affected rats manifested neurologie deficits accompanied by pathologie lesions. Brainstem infarcts developed in only a small proportion of rats without recognized risk factors after intracisternal injection of endotoxin. Thus, stroke risk factors, whieh are ordinarily regarded as operating through acceleration of atherosclerosis, may predispose to brain ischemia by local effects on brain mierocirculation such as those thought to underlie preparation of a tissue for the local Shwartzman reaction.
KW  - Gehirn
KW  - Durchblutung
Y1  - 1988
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-47971
ER  -