TY  - JOUR
A1  - Schülein-Völk, Christina
A1  - Wolf, Elmar
A1  - Zhu, Jing
A1  - Xu, Wenshan
A1  - Taranets, Lyudmyla
A1  - Hellmann, Andreas
A1  - Jänicke, Laura A.
A1  - Diefenbacher, Markus E.
A1  - Behrens, Axel
A1  - Eilers, Martin
A1  - Popov, Nikita
T1  - Dual Regulation of Fbw7 Function and Oncogenic Transformation by Usp28
JF  - CELL REPORTS
N2  - Fbw7, the substrate recognition subunit of SCF(Fbw7) ubiquitin ligase, mediates the turnover of multiple proto-oncoproteins and promotes its own degradation. Fbw7-dependent substrate ubiquitination is antagonized by the Usp28 deubiquitinase. Here, we show that Usp28 preferentially antagonizes autocatalytic ubiquitination and stabilizes Fbw7, resulting in dose-dependent effects in Usp28 knockout mice. Monoallelic deletion of Usp28 maintains stable Fbw7 but drives Fbw7 substrate degradation. In contrast, complete knockout triggers Fbw7 degradation and leads to the accumulation of Fbw7 substrates in several tissues and embryonic fibroblasts. On the other hand, overexpression of Usp28 stabilizes both Fbw7 and its substrates. Consequently, both complete loss and ectopic expression of Usp28 promote Ras-driven oncogenic transformation. We propose that dual regulation of Fbw7 activity by Usp28 is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 substrates, which is equivalently disrupted by loss or overexpression of Usp28.
KW  - Fbw7
KW  - oncogenic transformation
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-118219
SN  - 2211-1247
N1  - The sequencing data have been submitted to the GEO repository under accession number GSE59354.
VL  - 9
IS  - 3
ER  - 
TY  - JOUR
A1  - Luo, Yueming
A1  - Ling, Chuanren
A1  - Liu, Yangchen
A1  - Deng, Chong
A1  - Waaga-Gasser, Ana Maria
A1  - Chen, Minggui
A1  - He, Zehui
A1  - Chen, Erhui
A1  - Wei, Lin
A1  - Luo, Shimiao
A1  - Gong, Xiaozhen
A1  - Ye, Hong
A1  - Zhu, Jing
A1  - Song, Shan
A1  - Wang, Qiuting
A1  - Li, Shunmin
A1  - Gasser, Martin
A1  - Lin, Meizhen
T1  - The Beneficial Role of Auricular Point Pressure in Insomnia and Anxiety in Isolated COVID-19 Patients
JF  - Evidence-Based Complementary and Alternative Medicine
N2  - Background 
Coronavirus disease 2019 (COVID-19) causes psychological distress and can have a negative impact on the general mental health and rehabilitation in affected patients under currently implemented isolation guidelines. Auricular point pressure (APP) as well-established technique in traditional Chinese medicine may help to relieve sleep disturbance and anxiety in COVID-19 patients. 
Methods 
During the early phase of the epidemic/pandemic, patients were enrolled in this study (02/2020 until 03/2020 n = 84). They were strictly isolated on specific wards at the Hubei Provincial Hospital of Integrated Chinese and Western Medicine in Hubei. The retrospective cohort study design included two groups. Group A patients were treated with an auricular point pressure (APP) in addition to standard intensive care medicine while Group B participants (No-APP) received routine nursing measures alone. Treatment outcome was measured using the St. Mary’s Hospital Sleep Questionnaire (SMH) Score and the 7-Item Generalized Anxiety Disorder Scale (GAD-7). Both scores were measured in each patient at baseline and on the discharge day. 
Results 
The SMH score and sleep status changed in APP patients at the end of the treatment period when compared with No-APP patients (P < 0.01). APP-treated patients demonstrated lower GAD-7 scores than No-APP controls (P < 0.01). Further, no significant differences in safety or adverse events between the APP and No-APP groups were observed. Conclusion 
The results from our snapshot study during the early phase of the SARS-CoV-2 epidemic/pandemic suggest that auricular point pressure could be a simple and effective tool to relieve insomnia and situational anxiety in hospitalized patients suffering from COVID-19 and kept under disconcerting conditions of isolation.
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-369658
VL  - 2021
ER  -