TY  - JOUR
A1  - de Vreeze, Ronald S. A.
A1  - Coevorden, Frits van
A1  - Boerrigter, Lucie
A1  - Nederlof, Petra M.
A1  - Haas, Rick L.
A1  - Bras, Johannes
A1  - Rosenwald, Andreas
A1  - Mentzel, Thomas
A1  - de Jong, Daphne
T1  - Delineation of Chondroid Lipoma: An Immunohistochemical and Molecular Biological Analysis
JF  - Sarcoma
N2  - Aims 

Chondroid lipoma (CL) is a benign tumor that mimics a variety of soft tissue tumors and is characterized by translocation (11;16). Here, we analyze CL and its histological mimics. 

Methods 

CL ( ) was compared to a variety of histological mimics ( ) for morphological aspects and immunohistochemical features including cyclinD1(CCND1). Using FISH analysis, CCND1 and FUS were investigated as potential translocation partners. 

Results 

All CLs were strongly positive for CCND1. One of 4 myoepitheliomas, CCND1, was positive. In well-differentiated lipomatous tumors and in chondrosarcomas, CCND1 was frequently expressed, but all myxoid liposarcomas were negative. FISH analysis did not give support for direct involvement of CCND1 and FUS as translocation partners. 

Conclusions 

Chondroid lipoma is extremely rare and has several and more prevalent histological mimics. The differential diagnosis of chondroid lipomas can be unraveled using immunohistochemical and molecular support.
KW  - Lipom
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-135103
VL  - 2011
IS  - Article ID 638403
ER  -