TY  - JOUR
A1  - Hoffmann, Linda S.
A1  - Etzrodt, Jennifer
A1  - Willkomm, Lena
A1  - Sanyal, Abhishek
A1  - Scheja, Ludger
A1  - Fischer, Alexander W. C.
A1  - Stasch, Johannes-Peter
A1  - Bloch, Wilhelm
A1  - Friebe, Andreas
A1  - Heeren, Joerg
A1  - Pfeifer, Alexander
T1  - Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue
JF  - Nature Communications
N2  - Obesity is characterized by a positive energy balance and expansion of white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) combusts energy to produce heat. Here we show that a small molecule stimulator (BAY 41-8543) of soluble guanylyl cyclase (sGC), which produces the second messenger cyclic GMP (cGMP), protects against diet-induced weight gain, induces weight loss in established obesity, and also improves the diabetic phenotype. Mechanistically, the haeme-dependent sGC stimulator BAY 41-8543 enhances lipid uptake into BAT and increases whole-body energy expenditure, whereas ablation of the haeme-containing \(\beta\)\(_{1}\)-subunit of sGC severely impairs BAT function. Notably, the sGC stimulator enhances differentiation of human brown adipocytes as well as induces 'browning' of primary white adipocytes. Taken together, our data suggest that sGC is a potential pharmacological target for the treatment of obesity and its comorbidities.
KW  - decompensated heart failure
KW  - mitochondrial biogenesis
KW  - pulmonary hypertension
KW  - nitric oxide
KW  - erectile dysfunction
KW  - beige adipocytes
KW  - fat development
KW  - cGMP
KW  - riociguat
KW  - white
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-143127
VL  - 6
IS  - 7235
ER  - 
TY  - JOUR
A1  - Flachenecker, Peter
A1  - Bures, Anna Karoline
A1  - Gawlik, Angeli
A1  - Weiland, Ann-Christin
A1  - Kuld, Sarah
A1  - Gusowski, Klaus
A1  - Streber, René
A1  - Pfeifer, Klaus
A1  - Tallner, Alexander
T1  - Efficacy of an internet-based program to promote physical activity and exercise after inpatient rehabilitation in persons with multiple sclerosis: a randomized, single-blind, controlled study
JF  - International Journal of Environmental Research and Public Health
N2  - Background: Multimodal rehabilitation improves fatigue and mobility in persons with multiple sclerosis (PwMS). Effects are transient and may be conserved by internet-based physical activity promotion programs. Objective: Evaluate the effects of internet-based physical activity and exercise promotion on fatigue, quality of life, and gait in PwMS after inpatient rehabilitation. Methods: PwMS (Expanded Disability Status Scale (EDSS) ≤ 6.0, fatigue: Würzburg Fatigue Inventory for Multiple Sclerosis (WEIMuS) ≥ 32) were randomized into an intervention group (IG) or a control group (CG). After rehabilitation, IG received 3 months of internet-based physical activity promotion, while CG received no intervention. Primary outcome: self-reported fatigue (WEIMuS). Secondary outcomes: quality of life (Multiple Sclerosis Impact Scale 29, MSIS-29), gait (2min/10m walking test, Tinetti score). Measurements: beginning (T0) and end (T1) of inpatient rehabilitation, 3 (T2) and 6 (T3) months afterwards. Results: 64 of 84 PwMS were analyzed (IG: 34, CG: 30). After rehabilitation, fatigue decreased in both groups. At T2 and T3, fatigue increased again in CG but was improved in IG (p < 0.001). MSIS-29 improved in both groups at T1 but remained improved at T2 and T3 only in IG. Gait improvements were more pronounced in IG at T2. Conclusions: The study provides Class II evidence that the effects of rehabilitation on fatigue, quality of life, and gait can be maintained for 3–6 months with an internet-based physical activity and exercise promotion program.
KW  - multiple sclerosis
KW  - rehabilitation
KW  - fatigue
KW  - quality of life
KW  - walking
KW  - physical activity
KW  - exercise
KW  - online systems
KW  - internet-based intervention
KW  - health behavior
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-207863
SN  - 1660-4601
VL  - 17
IS  - 12
ER  -