TY  - JOUR
A1  - Holzapfel, Boris Michael
A1  - Chhaya, Mohit Prashant
A1  - Melchels, Ferry Petrus Wilhelmus
A1  - Holzapfel, Nina Pauline
A1  - Prodinger, Peter Michael
A1  - von Eisenhart-Rothe, Rüdiger
A1  - Griensven, Martijn van
A1  - Schantz, Jan-Thorsten
A1  - Rudert, Maximilian
A1  - Hutmacher, Dietmar Werner
T1  - Can Bone Tissue Engineering Contribute to Therapy Concepts after Resection of Musculoskeletal Sarcoma?
JF  - Sarcoma
N2  - Resection of musculoskeletal sarcoma can result in large bone defects where regeneration is needed in a quantity far beyond the normal potential of self-healing. In many cases, these defects exhibit a limited intrinsic regenerative potential due to an adjuvant therapeutic regimen, seroma, or infection. Therefore, reconstruction of these defects is still one of the most demanding procedures in orthopaedic surgery. The constraints of common treatment strategies have triggered a need for new therapeutic concepts to design and engineer unparalleled structural and functioning bone grafts. To satisfy the need for long-term repair and good clinical outcome, a paradigm shift is needed from methods to replace tissues with inert medical devices to more biological approaches that focus on the repair and reconstruction of tissue structure and function. It is within this context that the field of bone tissue engineering can offer solutions to be implemented into surgical therapy concepts after resection of bone and soft tissue sarcoma. In this paper we will discuss the implementation of tissue engineering concepts into the clinical field of orthopaedic oncology.
KW  - musculoskeletal sarcoma
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-132465
VL  - 2013
IS  - Article ID 153640
ER  - 
TY  - JOUR
A1  - Holzapfel, Boris Michael
A1  - Prodinger, Peter M.
A1  - Pilge, Hakan
A1  - Banke, Ingo J.
A1  - Bürklein, Dominik
A1  - Miethke, Thomas
A1  - Gradinger, Reiner
T1  - Acute Osteomyelitis of the Humerus mimicking Malignancy: Streptococcus pneumoniae as Exceptional Pathogen in an Immunocompetent Adult
JF  - BMC Infectious Diseases
N2  - Background

Chronic osteomyelitis due to direct bone trauma or vascular insufficiency is a frequent problem in orthopaedic surgery. In contrast, acute haematogenous osteomyelitis represents a rare entity that almost exclusively affects prepubescent children or immunodeficient adults.

Case Presentation

In this article, we report the case of acute pneumococcal osteomyelitis of the humerus in an immunocompetent and otherwise healthy 44-year-old male patient presenting with minor inflammation signs and misleading clinical features.

Conclusions

The diagnosis had to be confirmed by open biopsy which allowed the initiation of a targeted therapy. A case of pneumococcal osteomyelitis of a long bone, lacking predisposing factors or trauma, is unique in adults and has not been reported previously.
KW  - Acute osteomyelitis
KW  - Haematogenous
KW  - Long bones
KW  - Immunodeficiency
KW  - Osteomyelitis of the humerus
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-95790
ER  -