TY  - JOUR
A1  - Nagai, Michiaki
A1  - Förster, Carola Yvette
A1  - Dote, Keigo
T1  - Sex hormone-specific neuroanatomy of Takotsubo syndrome: is the insular cortex a moderator?
JF  - Biomolecules
N2  - Takotsubo syndrome (TTS), a transient form of dysfunction in the heart's left ventricle, occurs predominantly in postmenopausal women who have emotional stress. Earlier studies support the concept that the human circulatory system is modulated by a cortical network (consisting of the anterior cingulate gyrus, amygdala, and insular cortex (Ic)) that plays a pivotal role in the central autonomic nervous system in relation to emotional stressors. The Ic plays a crucial role in the sympathovagal balance, and decreased levels of female sex hormones have been speculated to change functional cerebral asymmetry, with a possible link to autonomic instability. In this review, we focus on the Ic as an important moderator of the human brain–heart axis in association with sex hormones. We also summarize the current knowledge regarding the sex-specific neuroanatomy in TTS.
KW  - insular cortex
KW  - autonomic nervous system
KW  - laterality
KW  - sex hormone
KW  - central autonomic network
KW  - Takotsubo cardiomyopathy
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-254776
SN  - 2218-273X
VL  - 12
IS  - 1
ER  - 
TY  - JOUR
A1  - Khan, Muhammad Usman
A1  - Pirzadeh, Maryam
A1  - Förster, Carola Yvette
A1  - Shityakov, Sergey
A1  - Shariati, Mohammad Ali
T1  - Role of milk-derived antibacterial peptides in modern food biotechnology: their synthesis, applications and future perspectives
JF  - Biomolecules
N2  - Milk-derived antibacterial peptides (ABPs) are protein fragments with a positive influence on the functions and conditions of a living organism. Milk-derived ABPs have several useful properties important for human health, comprising a significant antibacterial effect against various pathogens, but contain toxic side-effects. These compounds are mainly produced from milk proteins via fermentation and protein hydrolysis. However, they can also be produced using recombinant DNA techniques or organic synthesis. This review describes the role of milk-derived ABPs in modern food biotechnology with an emphasis on their synthesis and applications. Additionally, we also discuss the mechanisms of action and the main bioproperties of ABPs. Finally, we explore future perspectives for improving ABP physicochemical properties and diminishing their toxic side-effects.
KW  - milk proteins
KW  - bioactive peptide
KW  - antibacterial activity
KW  - fermentation
KW  - protein hydrolysis
KW  - recombinant DNA
KW  - peptide synthesis
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-197610
SN  - 2218-273X
VL  - 8
IS  - 4
ER  - 
TY  - JOUR
A1  - Fareed, Muhammad Mazhar
A1  - Qasmi, Maryam
A1  - Aziz, Shaan
A1  - Völker, Elisabeth
A1  - Förster, Carola Yvette
A1  - Shityakov, Sergey
T1  - The role of clusterin transporter in the pathogenesis of Alzheimer’s disease at the blood–brain barrier interface: a systematic review
JF  - Biomolecules
N2  - Alzheimer’s disease (AD) is considered a chronic and debilitating neurological illness that is increasingly impacting older-age populations. Some proteins, including clusterin (CLU or apolipoprotein J) transporter, can be linked to AD, causing oxidative stress. Therefore, its activity can affect various functions involving complement system inactivation, lipid transport, chaperone activity, neuronal transmission, and cellular survival pathways. This transporter is known to bind to the amyloid beta (Aβ) peptide, which is the major pathogenic factor of AD. On the other hand, this transporter is also active at the blood–brain barrier (BBB), a barrier that prevents harmful substances from entering and exiting the brain. Therefore, in this review, we discuss and emphasize the role of the CLU transporter and CLU-linked molecular mechanisms at the BBB interface in the pathogenesis of AD.
KW  - clusterin transporter
KW  - Wnt signaling
KW  - Alzheimer’s disease
KW  - AD pathogenesis
KW  - blood–brain barrier
KW  - apolipoprotein J
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-290279
SN  - 2218-273X
VL  - 12
IS  - 10
ER  -