TY  - JOUR
A1  - Pfennig, Andrea
A1  - Leopold, Karolina
A1  - Bechdolf, Andreas
A1  - Correll, Christoph U.
A1  - Holtmann, Martin
A1  - Lambert, Martin
A1  - Marx, Carolin
A1  - Meyer, Thomas D.
A1  - Pfeiffer, Steffi
A1  - Reif, Andreas
A1  - Rottmann-Wolf, Maren
A1  - Schmitt, Natalie M.
A1  - Stamm, Thomas
A1  - Juckel, Georg
A1  - Bauer, Michael
T1  - Early specific cognitive-behavioural psychotherapy in subjects at high risk for bipolar disorders: study protocol for a randomised controlled trial
JF  - TRIALS
N2  - Background: Bipolar disorders (BD) are among the most severe mental disorders with first clinical signs and symptoms frequently appearing in adolescence and early adulthood. The long latency in clinical diagnosis (and subsequent adequate treatment) adversely affects the course of disease, effectiveness of interventions and health-related quality of life, and increases the economic burden of BD. Despite uncertainties about risk constellations and symptomatology in the early stages of potentially developing BD, many adolescents and young adults seek help, and most of them suffer substantially from symptoms already leading to impairments in psychosocial functioning in school, training, at work and in their social relationships. We aimed to identify subjects at risk of developing BD and investigate the efficacy and safety of early specific cognitive-behavioural psychotherapy (CBT) in this subpopulation. 
Methods/Design: EarlyCBT is a randomised controlled multi-centre clinical trial to evaluate the efficacy and safety of early specific CBT, including stress management and problem solving strategies, with elements of mindfulness-based therapy (MBT) versus unstructured group meetings for 14 weeks each and follow-up until week 78. Participants are recruited at seven university hospitals throughout Germany, which provide in-and outpatient care (including early recognition centres) for psychiatric patients. Subjects at high risk must be 15 to 30 years old and meet the combination of specified affective symptomatology, reduction of psychosocial functioning, and family history for (schizo) affective disorders. Primary efficacy endpoints are differences in psychosocial functioning and defined affective symptomatology at 14 weeks between groups. Secondary endpoints include the above mentioned endpoints at 7, 24, 52 and 78 weeks and the change within groups compared to baseline; perception of, reaction to and coping with stress; and conversion to full BD. 
Discussion: To our knowledge, this is the first study to evaluate early specific CBT in subjects at high risk for BD. Structured diagnostic interviews are used to map the risk status and development of disease. With our study, the level of evidence for the treatment of those young patients will be significantly raised.
KW  - cognitive-behavioural psychotherapy
KW  - bipolar disorders
KW  - early recognition
KW  - intervention study
KW  - of-the-literature
KW  - ultra-high risk
KW  - spectrum disorder
KW  - early intervention
KW  - rating scale
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-116279
SN  - 1468-6694
SN  - 1745-6215
VL  - 15
IS  - 161
ER  - 
TY  - JOUR
A1  - Prasse, Tobias
A1  - Stratos, Ioannis
A1  - Niehoff, Anja
A1  - Christ, Hildegard
A1  - Heck, Vincent
A1  - Meyer, Carolin
A1  - Mittlmeier, Thomas
T1  - Bisphenol A-related effects on bone morphology and biomechanical properties in an animal model
JF  - Toxics
N2  - Bisphenol A (BPA), which is contained in numerous plastic products, is known to act as an endocrine-disruptive, toxic, and carcinogenic chemical. This experimental series sought to determine the influence of BPA exposure on the femoral bone architecture and biomechanical properties of male and female Wistar rats. BPA was applied subcutaneously by using osmotic pumps. After 12 weeks, the bones were analyzed by micro-computed tomography (micro-CT) and a three-point bending test. Comparing the female low- and high-dose groups, a significantly greater marrow area (p = 0.047) was identified in the group exposed to a higher BPA concentration. In addition, the trabecular number tended to be higher in the female high-dose group when compared to the low-dose group (p > 0.05). The area moment of inertia also tended to be higher in the male high-dose group when compared to the male low-dose group (p > 0.05). Considering our results, BPA-related effects on the bone morphology in female Wistar rats are osteoanabolic after high-dose exposure, while, in male rats, a tendency toward negative effects on the bone morphology in terms of a reduced cross-sectional cortical area and total area could be demonstrated.
KW  - bisphenol A
KW  - endocrine disruption
KW  - bone morphology
KW  - micro-computed tomography
KW  - mechanical property
KW  - three-point bending
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-262216
SN  - 2305-6304
VL  - 10
IS  - 2
ER  -