TY  - JOUR
A1  - Colvill, Emma
A1  - Booth, Jeremy
A1  - Nill, Simeon
A1  - Fast, Martin
A1  - Bedford, James
A1  - Oelfke, Uwe
A1  - Nakamura, Mitsuhiro
A1  - Poulsen, Per
A1  - Worm, Esben
A1  - Hansen, Rune
A1  - Ravkilde, Thomas
A1  - Rydhög, Jonas Scherman
A1  - Pommer, Tobias
A1  - af Rosenschold, Per Munck
A1  - Lang, Stephanie
A1  - Guckenberger, Matthias
A1  - Groh, Christian
A1  - Herrmann, Christian
A1  - Verellen, Dirk
A1  - Poels, Kenneth
A1  - Wang, Lei
A1  - Hadsell, Michael
A1  - Sothmann, Thilo
A1  - Blanck, Oliver
A1  - Keall, Paul
T1  - A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy: a multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking
JF  - Radiotherapy and Oncology
N2  - Purpose: A study of real-time adaptive radiotherapy systems was performed to test the hypothesis that, across delivery systems and institutions, the dosimetric accuracy is improved with adaptive treatments over non-adaptive radiotherapy in the presence of patient-measured tumor motion. Methods and materials: Ten institutions with robotic(2), gimbaled(2), MLC(4) or couch tracking(2) used common materials including CT and structure sets, motion traces and planning protocols to create a lung and a prostate plan. For each motion trace, the plan was delivered twice to a moving dosimeter; with and without real-time adaptation. Each measurement was compared to a static measurement and the percentage of failed points for gamma-tests recorded. Results: For all lung traces all measurement sets show improved dose accuracy with a mean 2%/2 mm gamma-fail rate of 1.6% with adaptation and 15.2% without adaptation (p < 0.001). For all prostate the mean 2%/2 mm gamma-fail rate was 1.4% with adaptation and 17.3% without adaptation (p < 0.001). The difference between the four systems was small with an average 2%/2 mm gamma-fail rate of <3% for all systems with adaptation for lung and prostate. Conclusions: The investigated systems all accounted for realistic tumor motion accurately and performed to a similar high standard, with real-time adaptation significantly outperforming non-adaptive delivery methods.
KW  - Robotic tracking
KW  - Gimbaled tracking
KW  - MLC tracking
KW  - Couch tracking
KW  - Organ motion
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-189605
VL  - 119
IS  - 1
ER  - 
TY  - JOUR
A1  - Grob, Robin
A1  - Tritscher, Clara
A1  - Grübel, Kornelia
A1  - Stigloher, Christian
A1  - Groh, Claudia
A1  - Fleischmann, Pauline N.
A1  - Rössler, Wolfgang
T1  - Johnston's organ and its central projections in Cataglyphis desert ants
JF  - Journal of Comparative Neurology
N2  - The Johnston's organ (JO) in the insect antenna is a multisensory organ involved in several navigational tasks including wind‐compass orientation, flight control, graviception, and, possibly, magnetoreception. Here we investigate the three dimensional anatomy of the JO and its neuronal projections into the brain of the desert ant Cataglyphis, a marvelous long‐distance navigator. The JO of C. nodus workers consists of 40 scolopidia comprising three sensory neurons each. The numbers of scolopidia slightly vary between different sexes (female/male) and castes (worker/queen). Individual scolopidia attach to the intersegmental membrane between pedicel and flagellum of the antenna and line up in a ring‐like organization. Three JO nerves project along the two antennal nerve branches into the brain. Anterograde double staining of the antennal afferents revealed that JO receptor neurons project to several distinct neuropils in the central brain. The T5 tract projects into the antennal mechanosensory and motor center (AMMC), while the T6 tract bypasses the AMMC via the saddle and forms collaterals terminating in the posterior slope (PS) (T6I), the ventral complex (T6II), and the ventrolateral protocerebrum (T6III). Double labeling of JO and ocellar afferents revealed that input from the JO and visual information from the ocelli converge in tight apposition in the PS. The general JO anatomy and its central projection patterns resemble situations in honeybees and Drosophila. The multisensory nature of the JO together with its projections to multisensory neuropils in the ant brain likely serves synchronization and calibration of different sensory modalities during the ontogeny of navigation in Cataglyphis.
KW  - ant brain
KW  - chordotonal organ
KW  - graviception
KW  - magnetic compass
KW  - multisensory integration
KW  - navigation
KW  - wind compass
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225679
VL  - 529
IS  - 8
SP  - 2138
EP  - 2155
ER  -