TY - BOOK A1 - Herb, Christopher T1 - Restrukturierung von Wertschöpfungsketten in der Digitalisierung. Eine Analyse der deutschen Schuhbranche vom Hersteller bis zum Konsumenten T1 - Restructuring of value chains in digitalization. An analysis of the German footwear sector from manufacturer to consumer N2 - Globale Wertschöpfungsketten stellen nicht nur hochkomplexe Beziehungsgefüge dar, sondern unterliegen auch einem ständigen Wandlungsprozess. Ein zentraler Treiber dieser Wandlungsprozesse ist der technologische Fortschritt. Moderne Informations- und Kommunikationstechnologien, insbesondere die Phänomene der Digitalisierung und des Online-Handels, sind derzeit von besonderer Bedeutung für Wertschöpfungsketten, da unterschiedliche Fortschritte in der Digitalisierung nicht nur zu wirtschaftlichen Vor- und Nachteilen von Unternehmen führen können, sondern auch zu Up- bzw. Downgradingprozessen innerhalb der Wertschöpfungsketten. In der vorliegenden Studie wird der Fokus auf den handels- bzw. konsumentennahen Teil von Wertschöpfungsketten gelegt, um die Folgen der Digitalisierung für Hersteller, Händler und Konsumenten näher zu betrachten. Als konkretes Forschungsbeispiel dient die deutsche Schuhbranche, da sich diese gegenwärtig – von Industrie bis Handel – in einem umfassenden Strukturwandel befindet. Die Analyse zeigt, dass sich die Komplexität von Wertschöpfungsketten im Zuge der Digitalisierung deutlich erhöht (hat). In der Schuhbranche drängen neue Akteure auf den Markt, bestehende Akteure müssen sich anpassen. Direkte Folgen sind nicht nur eine neue Akteurskonstellation, sondern auch ein sich neu bildendes Machtgefüge. Es kommt somit zur Restrukturierung bisheriger Wertschöpfungsketten. N2 - Global value chains (GVC) not only represent highly complex structures of relationships, but are also subject to a constant process of change. A key driver of these processes of change is technological progress. Modern information and communication technologies, especially the phenomena of digitalization and e-commerce, are currently of particular importance for GVC, as different advances in digitalization can lead not only to economic advantages and disadvantages for companies, but also to up- or downgrading processes within GVC. This study examines on the retail- and consumer-related part of GVC in order to investigate the consequences of digitalization for manufacturers, retailers and consumers. The German footwear sector serves as a specific research example, as it is currently undergoing major structural change – from industry to retail. The analysis shows that the complexity of GVC has increased significantly in the course of digitalization. In the footwear sector, new players are entering the market and existing players have to adapt. Direct consequences are not only a new constellation of players, but also a newly forming power structure. This results in the re-organization of previous value chains. T3 - Geographische Handelsforschung - 32 KW - Wertschöpfungskette KW - Schuh KW - Digitalisierung KW - Einzelhandel KW - Wertschöpfungsketten KW - Schuhbranche KW - Digitalisierung KW - Governance KW - Konsumentenverhalten KW - Global Value Chains KW - Footwear sector KW - Digitalization KW - Governance KW - Consumer behavior Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-269564 SN - 978-3-95826-186-0 SN - 978-3-95826-187-7 SN - 2626-8906 SN - 2196-5811 N1 - Dissertation, RWTH Aachen, 2021 N1 - Parallel erschienen als Druckausgabe in Würzburg University Press, ISBN 978-3-95826-186-0, 34,90 EUR PB - Würzburg University Press CY - Würzburg ER - TY - INPR A1 - Hennig, Thomas A1 - Prusty, Archana B. A1 - Kaufer, Benedikt A1 - Whisnant, Adam W. A1 - Lodha, Manivel A1 - Enders, Antje A1 - Thomas, Julius A1 - Kasimir, Francesca A1 - Grothey, Arnhild A1 - Herb, Stefanie A1 - Jürges, Christopher A1 - Meister, Gunter A1 - Erhard, Florian A1 - Dölken, Lars A1 - Prusty, Bhupesh K. T1 - Selective inhibition of microRNA processing by a herpesvirus-encoded microRNA triggers virus reactivation from latency N2 - Herpesviruses have mastered host cell modulation and immune evasion to augment productive infection, life-long latency and reactivation thereof 1,2. A long appreciated, yet elusively defined relationship exists between the lytic-latent switch and viral non-coding RNAs 3,4. Here, we identify miRNA-mediated inhibition of miRNA processing as a novel cellular mechanism that human herpesvirus 6A (HHV-6A) exploits to disrupt mitochondrial architecture, evade intrinsic host defense and drive the latent-lytic switch. We demonstrate that virus-encoded miR-aU14 selectively inhibits the processing of multiple miR-30 family members by direct interaction with the respective pri-miRNA hairpin loops. Subsequent loss of miR-30 and activation of miR-30/p53/Drp1 axis triggers a profound disruption of mitochondrial architecture, which impairs induction of type I interferons and is necessary for both productive infection and virus reactivation. Ectopic expression of miR-aU14 was sufficient to trigger virus reactivation from latency thereby identifying it as a readily drugable master regulator of the herpesvirus latent-lytic switch. Our results show that miRNA-mediated inhibition of miRNA processing represents a generalized cellular mechanism that can be exploited to selectively target individual members of miRNA families. We anticipate that targeting miR-aU14 provides exciting therapeutic options for preventing herpesvirus reactivations in HHV-6-associated disorders like myalgic encephalitis/chronic fatigue syndrome (ME/CFS) and Long-COVID. KW - Herpesvirus KW - HHV-6 KW - miRNA processing KW - miR-30 KW - mitochondria KW - fusion and fission KW - type I interferon KW - latency KW - virus reactivation Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-267858 UR - https://doi.org/10.21203/rs.3.rs-820696/v1 ET - submitted version ER - TY - INPR A1 - Hennig, Thomas A1 - Prusty, Archana B. A1 - Kaufer, Benedikt A1 - Whisnant, Adam W. A1 - Lodha, Manivel A1 - Enders, Antje A1 - Thomas, Julius A1 - Kasimir, Francesca A1 - Grothey, Arnhild A1 - Herb, Stefanie A1 - Jürges, Christopher A1 - Meister, Gunter A1 - Erhard, Florian A1 - Dölken, Lars A1 - Prusty, Bhupesh K. T1 - Selective inhibition of miRNA 1 processing by a herpesvirus encoded miRNA N2 - Herpesviruses have mastered host cell modulation and immune evasion to augment productive infection, life-long latency and reactivation thereof 1,2. A long appreciated, yet elusively defined relationship exists between the lytic-latent switch and viral non-coding RNAs 3,4. Here, we identify miRNA-mediated inhibition of miRNA processing as a thus far unknown cellular mechanism that human herpesvirus 6A (HHV-6A) exploits to disrupt mitochondrial architecture, evade intrinsic host defense and drive the lytic-latent switch. We demonstrate that virus-encoded miR-aU14 selectively inhibits the processing of multiple miR-30 family members by direct interaction with the respective pri-miRNA hairpin loops. Subsequent loss of miR-30 and activation of the miR-30/p53/Drp1 axis triggers a profound disruption of mitochondrial architecture. This impairs induction of type I interferons and is necessary for both productive infection and virus reactivation. Ectopic expression of miR-aU14 triggered virus reactivation from latency, identifying viral miR-aU14 as a readily drugable master regulator of the herpesvirus lytic-latent switch. Our results show that miRNA-mediated inhibition of miRNA processing represents a generalized cellular mechanism that can be exploited to selectively target individual members of miRNA families. We anticipate that targeting miR-aU14 provides exciting therapeutic options for preventing herpesvirus reactivations in HHV-6-associated disorders. KW - Herpesvirus KW - HHV-6A KW - miRNA processing KW - miR-30 KW - mitochondria KW - fusion and fission KW - type I interferon KW - latency KW - virus reactivation Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-267862 ET - accepted version ER -