TY  - INPR
A1  - Huber, Bernhard
A1  - Pres, Sebastian
A1  - Wittmann, Emanuel
A1  - Dietrich, Lysanne
A1  - Lüttig, Julian
A1  - Fersch, Daniel
A1  - Krauss, Enno
A1  - Friedrich, Daniel
A1  - Kern, Johannes
A1  - Lisinetskii, Victor
A1  - Hensen, Matthias
A1  - Hecht, Bert
A1  - Bratschitsch, Rudolf
A1  - Riedle, Eberhard
A1  - Brixner, Tobias
T1  - Space- and time-resolved UV-to-NIR surface spectroscopy and 2D nanoscopy at 1 MHz repetition rate
N2  - We describe a setup for time-resolved photoemission electron microscopy (TRPEEM) with aberration correction enabling 3 nm spatial resolution and sub-20 fs temporal resolution. The latter is realized by our development of a widely tunable (215–970 nm) noncollinear optical parametric amplifier (NOPA) at 1 MHz repetition rate. We discuss several exemplary applications. Efficient photoemission from plasmonic Au nanoresonators is investigated with phase-coherent pulse pairs from an actively stabilized interferometer. More complex excitation fields are created with a liquid-crystal-based pulse shaper enabling amplitude and phase shaping of NOPA pulses with spectral components from 600 to 800 nm. With this system we demonstrate spectroscopy within a single plasmonic nanoslit resonator by spectral amplitude shaping and investigate the local field dynamics with coherent two-dimensional (2D) spectroscopy at the nanometer length scale (“2D nanoscopy”). We show that the local response varies across a distance as small as 33 nm in our sample. Further, we report two-color pump–probe experiments using two independent NOPA beamlines. We extract local variations of the excited-state dynamics of a monolayered 2D material (WSe2) that we correlate with low-energy electron microscopy (LEEM) and reflectivity (LEER) measurements. Finally, we demonstrate the in-situ sample preparation capabilities for organic thin films and their characterization via spatially resolved electron diffraction and dark-field LEEM.
KW  - Photoemission electron microscopy PEEM
KW  - Low energy electron microscopy LEEM
KW  - Spatially resolved 2D spectroscopy
KW  - Two-color pump-probe spectroscopy
KW  - Time-resolved photoemission electron microscopy
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-191906
SN  - 0034-6748
N1  - This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Review of Scientific Instruments 90, 113103 (2019); https://doi.org/10.1063/1.5115322 and may be found at https://doi.org/10.1063/1.5115322.
ER  - 
TY  - JOUR
A1  - Ferger, Matthias
A1  - Ban, Željka
A1  - Krošl, Ivona
A1  - Tomić, Sanja
A1  - Dietrich, Lena
A1  - Lorenzen, Sabine
A1  - Rauch, Florian
A1  - Sieh, Daniel
A1  - Friedrich, Alexandra
A1  - Griesbeck, Stefanie
A1  - Kenđel, Adriana
A1  - Miljanić, Snežana
A1  - Piantanida, Ivo
A1  - Marder, Todd B.
T1  - Bis(phenylethynyl)arene Linkers in Tetracationic Bis-triarylborane Chromophores Control Fluorimetric and Raman Sensing of Various DNAs and RNAs
JF  - Chemistry-A European Journal
N2  - We report four new luminescent tetracationic bis-triarylborane DNA and RNA sensors that show high binding affinities, in several cases even in the nanomolar range. Three of the compounds contain substituted, highly emissive and structurally flexible bis(2,6-dimethylphenyl-4-ethynyl)arene linkers (3: arene=5,5′-2,2′-bithiophene; 4: arene=1,4-benzene; 5: arene=9,10-anthracene) between the two boryl moieties and serve as efficient dual Raman and fluorescence chromophores. The shorter analogue 6 employs 9,10-anthracene as the linker and demonstrates the importance of an adequate linker length with a certain level of flexibility by exhibiting generally lower binding affinities than 3–5. Pronounced aggregation–deaggregation processes are observed in fluorimetric titration experiments with DNA for compounds 3 and 5. Molecular modelling of complexes of 5 with AT-DNA, suggest the minor groove as the dominant binding site for monomeric 5, but demonstrate that dimers of 5 can also be accommodated. Strong SERS responses for 3–5 versus a very weak response for 6, particularly the strong signals from anthracene itself observed for 5 but not for 6, demonstrate the importance of triple bonds for strong Raman activity in molecules of this compound class. The energy of the characteristic stretching vibration of the C≡C bonds is significantly dependent on the aromatic moiety between the triple bonds. The insertion of aromatic moieties between two C≡C bonds thus offers an alternative design for dual Raman and fluorescence chromophores, applicable in multiplex biological Raman imaging.
KW  - boranes
KW  - Raman probes
KW  - molecular modelling
KW  - fluorescent probes
KW  - DNA/RNA sensors
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-256717
VL  - 27
IS  - 16
ER  - 
TY  - JOUR
A1  - Kämmerer, Peer W.
A1  - Tribius, Silke
A1  - Cohrs, Lena
A1  - Engler, Gabriel
A1  - Ettl, Tobias
A1  - Freier, Kolja
A1  - Frerich, Bernhard
A1  - Ghanaati, Shahram
A1  - Gosau, Martin
A1  - Haim, Dominik
A1  - Hartmann, Stefan
A1  - Heiland, Max
A1  - Herbst, Manuel
A1  - Hoefert, Sebastian
A1  - Hoffmann, Jürgen
A1  - Hölzle, Frank
A1  - Howaldt, Hans-Peter
A1  - Kreutzer, Kilian
A1  - Leonhardt, Henry
A1  - Lutz, Rainer
A1  - Moergel, Maximilian
A1  - Modabber, Ali
A1  - Neff, Andreas
A1  - Pietzka, Sebastian
A1  - Rau, Andrea
A1  - Reichert, Torsten E.
A1  - Smeets, Ralf
A1  - Sproll, Christoph
A1  - Steller, Daniel
A1  - Wiltfang, Jörg
A1  - Wolff, Klaus-Dietrich
A1  - Kronfeld, Kai
A1  - Al-Nawas, Bilal
T1  - Adjuvant radiotherapy in patients with squamous cell carcinoma of the oral cavity or oropharynx and solitary ipsilateral lymph node metastasis (pN1) — a prospective multicentric cohort study
JF  - Cancers
N2  - (1) Background: Evaluation of impact of adjuvant radiation therapy (RT) in patients with oral squamous cell carcinoma of the oral cavity/oropharynx (OSCC) of up to 4 cm (pT1/pT2) and solitary ipsilateral lymph node metastasis (pN1). A non-irradiated group with clinical follow-up was chosen for control, and survival and quality of life (QL) were compared; (2) Methods: This prospective multicentric comprehensive cohort study included patients with resected OSCC (pT1/pT2, pN1, and cM0) who were allocated into adjuvant radiation therapy (RT) or observation. The primary endpoint was overall survival. Secondary endpoints were progression-free survival and QL after surgery; (3) Results: Out of 27 centers, 209 patients were enrolled with a median follow-up of 3.4 years. An amount of 137 patients were in the observation arm, and 72 received adjuvant irradiation. Overall survival did not differ between groups (hazard ratio (HR) 0.98 [0.55–1.73], p = 0.94). There were fewer neck metastases (HR 0.34 [0.15–0.77]; p = 0.01), as well as fewer local recurrences (HR 0.41 [0.19–0.89]; p = 0.02) under adjuvant RT. For QL, irradiated patients showed higher values for the symptom scale pain after 0.5, two, and three years (all p < 0.05). After six months and three years, irradiated patients reported higher symptom burdens (impaired swallowing, speech, as well as teeth-related problems (all p < 0.05)). Patients in the RT group had significantly more problems with mouth opening after six months, one, and two years (p < 0.05); (4) Conclusions: Adjuvant RT in patients with early SCC of the oral cavity and oropharynx does not seem to influence overall survival, but it positively affects progression-free survival. However, irradiated patients report a significantly decreased QL up to three years after therapy compared to the observation group.
KW  - oral squamous cell carcinoma
KW  - oropharyngeal carcinoma
KW  - surgery
KW  - resection
KW  - radiotherapy
KW  - survival
KW  - progression-free survival
KW  - quality of life
KW  - prospective
KW  - multicentric
KW  - lymph node
KW  - pN1
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-311024
SN  - 2072-6694
VL  - 15
IS  - 6
ER  - 
TY  - JOUR
A1  - Barile, Frank A.
A1  - Berry, Colin
A1  - Blaauboer, Bas
A1  - Boobis, Alan
A1  - Bolt, Herrmann M.
A1  - Borgert, Christopher
A1  - Dekant, Wolfgang
A1  - Dietrich, Daniel
A1  - Domingo, Jose L.
A1  - Galli, Corrado L.
A1  - Gori, Gio Batta
A1  - Greim, Helmut
A1  - Hengstler, Jan G.
A1  - Heslop-Harrison, Pat
A1  - Kacew, Sam
A1  - Marquardt, Hans
A1  - Mally, Angela
A1  - Pelkonen, Olavi
A1  - Savolainen, Kai
A1  - Testai, Emanuela
A1  - Tsatsakis, Aristides
A1  - Vermeulen, Nico P.
T1  - The EU chemicals strategy for sustainability: in support of the BfR position
JF  - Archives of Toxicology
N2  - The EU chemicals strategy for sustainability (CSS) asserts that both human health and the environment are presently threatened and that further regulation is necessary. In a recent Guest Editorial, members of the German competent authority for risk assessment, the BfR, raised concerns about the scientific justification for this strategy. The complexity and interdependence of the networks of regulation of chemical substances have ensured that public health and wellbeing in the EU have continuously improved. A continuous process of improvement in consumer protection is clearly desirable but any initiative directed towards this objective must be based on scientific knowledge. It must not confound risk with other factors in determining policy. This conclusion is fully supported in the present Commentary including the request to improve both, data collection and the time-consuming and bureaucratic procedures that delay the publication of regulations.
KW  - pharmacology/toxicology
KW  - occupational medicine/industrial medicine
KW  - environmental health
KW  - biomedicine, general
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-307154
SN  - 0340-5761
SN  - 1432-0738
VL  - 95
IS  - 9
ER  -