TY  - THES
A1  - Helf, Daniel
T1  - Beschreibung des Bowditch-Effektes in Abhängigkeit der Ausprägung einer Herzinsuffizienz am Tiermodell
T1  - Characterization of the Bowditch effect according to the developement of congestive heart failure in an animal model
N2  - Bei den primär herzgesunden Tieren wurde durch Frequenz-Überstimulation mit Hilfe eines implantierten biventrikulären Herzschrittmachers eine chronische Herzinsuffizienz induziert. Im Rahmen der Verlaufsbeobachtungen wurde in-vivo die Druckanstiegsgeschwindigkeit dP/dtmax, der enddiastolische sowie endsystolische Druck durch einen implantierten Drucksensor gemessen.  Anhand der gemessen dP/dtmax-, EDP- und ESP-Werte konnte der Bowditcheffekt dargestellt werden. Mit Ausprägung einer chronischen Herzinsuffizienz fiel dieser im Verlauf deutlich geringer aus, blieb aber stets nachweisbar.
N2  - Congestive heart failure was induced in initially healthy adult sheep by frequency overstimulation. On the basis of velocity of pressure rise (dP/dtmax), endsystolic pressure (ESP) and enddiastolic pressure (EDP) Bowditch effect was demonstrated. Along with the developement of a congestive heart failure Bowditch effect decreased but was throughout detectable.
KW  - Treppenphänomen
KW  - Herzinsuffizienz
KW  - Bowditcheffekt
KW  - Tiermodell
KW  - Frequenzüberstimulation
KW  - Congestiv Heart Failure
KW  - Force-frequency relation
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-219181
ER  - 
TY  - JOUR
A1  - Helmer, Philipp
A1  - Helf, Daniel
A1  - Sammeth, Michael
A1  - Winkler, Bernd
A1  - Hottenrott, Sebastian
A1  - Meybohm, Patrick
A1  - Kranke, Peter
T1  - The use of non-invasive continuous blood pressure measuring (ClearSight\(^®\)) during central neuraxial anaesthesia for caesarean section — a retrospective validation study
JF  - Journal of Clinical Medicine
N2  - Background: The close monitoring of blood pressure during a caesarean section performed under central neuraxial anaesthesia should be the standard of safe anaesthesia. As classical oscillometric and invasive blood pressure measuring have intrinsic disadvantages, we investigated a novel, non-invasive technique for continuous blood pressure measuring. Methods: In this monocentric, retrospective data analysis, the reliability of continuous non-invasive blood pressure measuring using ClearSight\(^®\) (Edwards Lifesciences Corporation) is validated in 31 women undergoing central neuraxial anaesthesia for caesarean section. In addition, patients and professionals evaluated ClearSight\(^®\) through questioning. Results: 139 measurements from 11 patients were included in the final analysis. Employing Bland–Altman analyses, we identified a bias of −10.8 mmHg for systolic, of −0.45 mmHg for diastolic and of +0.68 mmHg for mean arterial blood pressure measurements. Pooling all paired measurements resulted in a Pearson correlation coefficient of 0.7 for systolic, of 0.67 for diastolic and of 0.75 for mean arterial blood pressure. Compensating the interindividual differences in linear regressions of the paired measurements provided improved correlation coefficients of 0.73 for systolic, of 0.9 for diastolic and of 0.89 for mean arterial blood pressure measurements. Discussion: Diastolic and mean arterial blood pressure are within an acceptable range of deviation from the reference method, according to the Association for the Advancement of Medical Instrumentation (AAMI) in the patient collective under study. Both patients and professionals prefer ClearSight\(^®\) to oscillometric blood pressure measurement in regard of comfort and handling.
KW  - volume clamp
KW  - epidural anaesthesia
KW  - supine hypotensive syndrome
KW  - ClearSight\(^®\)
KW  - Bland–Altman
KW  - Fisher Z-score transformation
KW  - Pearson correlation coefficient
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-286042
SN  - 2077-0383
VL  - 11
IS  - 15
ER  -