TY  - JOUR
A1  - Megas, Ioannis-Fivos
A1  - Simons, David
A1  - Kim, Bong-Sung
A1  - Stoppe, Christian
A1  - Piatkowski, Andrzej
A1  - Fikatas, Panagiotis
A1  - Fuchs, Paul Christian
A1  - Bastiaanse, Jacqueline
A1  - Pallua, Norbert
A1  - Bernhagen, Jürgen
A1  - Grieb, Gerrit
T1  - Macrophage migration inhibitory factor — an innovative indicator for free flap ischemia after microsurgical reconstruction
JF  - Healthcare
N2  - (1) Background: Nowadays, the use of microsurgical free flaps is a standard operative procedure in reconstructive surgery. Still, thrombosis of the microanastomosis is one of the most fatal postoperative complications. Clinical evaluation, different technical devices and laboratory markers are used to monitor critical flap perfusion. Macrophage migration inhibitory factor (MIF), a structurally unique cytokine with chemokine-like characteristics, could play a role in predicting vascular problems and the failure of flap perfusion. (2) Methods: In this prospective observational study, 26 subjects that underwent microsurgical reconstruction were observed. Besides clinical data, the number of blood leukocytes, CRP and MIF were monitored. (3) Results: Blood levels of MIF, C-reactive protein (CRP) and leukocytes increased directly after surgery. Subjects that needed surgical revision due to thrombosis of the microanastomosis showed significantly higher blood levels of MIF than subjects without revision. (4) Conclusion: We conclude that MIF is a potential and innovative indicator for thrombosis of the microanastomosis after free flap surgery. Since it is easy to obtain diagnostically, MIF could be an additional tool to monitor flap perfusion besides clinical and technical assessments.
KW  - macrophage migration inhibitory factor (MIF)
KW  - free flap surgery
KW  - innovative surgical methods
KW  - microanastomosis
KW  - ischemia
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-239632
SN  - 2227-9032
VL  - 9
IS  - 6
ER  - 
TY  - JOUR
A1  - Gámez-Virués, Sagrario
A1  - Perović, David J.
A1  - Gossner, Martin M.
A1  - Börschig, Carmen
A1  - Blüthgen, Nico
A1  - de Jong, Heike
A1  - Simons, Nadja K.
A1  - Klein, Alexandra-Maria
A1  - Krauss, Jochen
A1  - Maier, Gwen
A1  - Scherber, Christoph
A1  - Steckel, Juliane
A1  - Rothenwöhrer, Christoph
A1  - Steffan-Dewenter, Ingolf
A1  - Weiner, Christiane N.
A1  - Weisser, Wolfgang
A1  - Werner, Michael
A1  - Tscharntke, Teja
A1  - Westphal, Catrin
T1  - Landscape simplification filters species traits and drives biotic homogenization
JF  - Nature Communications
N2  - Biodiversity loss can affect the viability of ecosystems by decreasing the ability of communities to respond to environmental change and disturbances. Agricultural intensification is a major driver of biodiversity loss and has multiple components operating at different spatial scales: from in-field management intensity to landscape-scale simplification. Here we show that landscape-level effects dominate functional community composition and can even buffer the effects of in-field management intensification on functional homogenization, and that animal communities in real-world managed landscapes show a unified response (across orders and guilds) to both landscape-scale simplification and in-field intensification. Adults and larvae with specialized feeding habits, species with shorter activity periods and relatively small body sizes are selected against in simplified landscapes with intense in-field management. Our results demonstrate that the diversity of land cover types at the landscape scale is critical for maintaining communities, which are functionally diverse, even in landscapes where in-field management intensity is high.
KW  - land-use intensity
KW  - community functional-responses
KW  - body-size
KW  - agricultural intensification
KW  - sustainable intensification
KW  - managed grasslands
KW  - biodiversity
KW  - diversity
KW  - heterogenity
KW  - butterflies
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-141925
VL  - 6
IS  - 8568
ER  -