TY  - JOUR
A1  - Haring, Bernhard
A1  - Reiner, Alexander P.
A1  - Liu, Jungmin
A1  - Tobias, Deirdre K.
A1  - Whitsel, Eric
A1  - Berger, Jeffrey S.
A1  - Desai, Pinkal
A1  - Wassertheil-Smoller, Sylvia
A1  - LaMonte, Michael J.
A1  - Hayden, Kathleen
A1  - Bick, Alexander G.
A1  - Natarajan, Pradeep
A1  - Weinstock, Joshua S.
A1  - Nguyen, Patricia K.
A1  - Stefanick, Marcia
A1  - Simon, Michael S.
A1  - Eaton, Charles
A1  - Kooperberg, Charles
A1  - Manson, JoAnn E.
T1  - Healthy Lifestyle and Clonal Hematopoiesis of Indeterminate Potential. Results from the Women’s Health Initiative
JF  - Journal of the American Heart Association
N2  - Background
Presence of clonal hematopoiesis of indeterminate potential (CHIP) is associated with a higher risk of atherosclerotic cardiovascular disease, cancer, and mortality. The relationship between a healthy lifestyle and CHIP is unknown.

Methods and Results
This analysis included 8709 postmenopausal women (mean age, 66.5 years) enrolled in the WHI (Women's Health Initiative), free of cancer or cardiovascular disease, with deep‐coverage whole genome sequencing data available. Information on lifestyle factors (body mass index, smoking, physical activity, and diet quality) was obtained, and a healthy lifestyle score was created on the basis of healthy criteria met (0 point [least healthy] to 4 points [most healthy]). CHIP was derived on the basis of a prespecified list of leukemogenic driver mutations. The prevalence of CHIP was 8.6%. A higher healthy lifestyle score was not associated with CHIP (multivariable‐adjusted odds ratio [OR] [95% CI], 0.99 [0.80–1.23] and 1.13 [0.93–1.37]) for the upper (3 or 4 points) and middle category (2 points), respectively, versus referent (0 or 1 point). Across score components, a normal and overweight body mass index compared with obese was significantly associated with a lower odds for CHIP (OR, 0.71 [95% CI, 0.57–0.88] and 0.83 [95% CI, 0.68–1.01], respectively; P‐trend 0.0015). Having never smoked compared with being a current smoker tended to be associated with lower odds for CHIP.

Conclusions
A healthy lifestyle, based on a composite score, was not related to CHIP among postmenopausal women. However, across individual lifestyle factors, having a normal body mass index was strongly associated with a lower prevalence of CHIP. These findings support the idea that certain healthy lifestyle factors are associated with a lower frequency of CHIP.
KW  - body mass index
KW  - clonal hematopoiesis of indeterminate potential
KW  - diet
KW  - lifestyle
KW  - physical activity
KW  - smoking
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-236146
VL  - 10
IS  - 5
ER  -