TY  - THES
A1  - Koch, Franziska
T1  - Die natriuretischen Peptide ANP, BNP und CNP stimulieren die Kommunikation zwischen Perizyten und Endothelzellen während der physiologischen Angiogenese.
T1  - The natriuretic peptides ANP, BNP and CNP stimulate the communication between pericytes and endothelial cells during physiological angiogenesis.
N2  - Sowohl der ANP und BNP bindende Guanylylzyklase-A-Rezeptor, als auch der CNP bindende Guanylylzyklase-B-Rezeptor auf den die Endothelzellen ummantelnden Perizyten sind für eine normale postnatale Gefäßentwicklung in der Netzhaut der Maus von entscheidender Bedeutung. Eine perizytenspezifische Deletion der Guanylylzyklase-Rezeptoren führt in Mäusen zu einer signifikanten Verminderung der postnatalen Ausdehnung sowie der Dichte des Gefäßnetzes. Dies ist nicht auf eine Verminderung der Bedeckung des Endothels durch Perizyten zurückzuführen. Weiterhin geht diese Rezeptordeletion mit einer geschlechterunabhängigen Erhöhung des systolischen Blutdrucks einher. Die intrazelluläre Weiterleitung, des durch die natriuretischen Peptide ausgelösten cGMP-Signals erfolgt über die cGMP-abhängige Proteinkinase Typ I (cGKI).
N2  - Both the ANP- and BNP-binding guanylyl cyclase A receptor and the CNP-binding guanylyl cyclase B receptor on pericytes lining endothelial cells are crucial for a normal postnatal vascular development in the mouse retina. A pericyte-specific deletion of the guanylyl cyclase receptors in mice leads to a significant reduction in the postnatal extent and density of the vascular plexus. This reduction is not caused by a reduced pericyte-coverage of the endothelium. Furthermore, the deletion of this receptor is associated with a gender-independent increase in systolic blood pressure. The intracellular transmission of the cGMP signal triggered by the natriuretic peptides takes place via the cGMP-dependent protein kinase type I (cGKI).
KW  - physiologiesche Angiogene
KW  - natiuretische Peptide
KW  - Guanylylzyklase-Rezeptoren
KW  - cGKI
KW  - Angiopoietin-1
KW  - Angiogenese
KW  - ANP
KW  - BNP
KW  - CNP
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-276598
ER  - 
TY  - JOUR
A1  - Dostál, Jakub
A1  - Fennel, Franziska
A1  - Koch, Federico
A1  - Herbst, Stefanie
A1  - Würthner, Frank
A1  - Brixner, Tobias
T1  - Direct observation of exciton–exciton interactions
JF  - Nature Communications
N2  - Natural light harvesting as well as optoelectronic and photovoltaic devices depend on efficient transport of energy following photoexcitation. Using common spectroscopic methods, however, it is challenging to discriminate one-exciton dynamics from multi-exciton interactions that arise when more than one excitation is present in the system. Here we introduce a coherent two-dimensional spectroscopic method that provides a signal only in case that the presence of one exciton influences the behavior of another one. Exemplarily, we monitor exciton diffusion by annihilation in a perylene bisimide-based J-aggregate. We determine quantitatively the exciton diffusion constant from exciton–exciton-interaction 2D spectra and reconstruct the annihilation-free dynamics for large pump powers. The latter enables for ultrafast spectroscopy at much higher intensities than conventionally possible and thus improves signal-to-noise ratios for multichromophore systems; the former recovers spatio–temporal dynamics for a broad range of phenomena in which exciton interactions are present.
KW  - energy transfer
KW  - self-assembly
KW  - optical spectroscopy
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226271
VL  - 9
ER  -