TY  - JOUR
A1  - Verrua, Elisa
A1  - Ferrante, Emanuele
A1  - Filopanti, Marcello
A1  - Malchiodi, Elena
A1  - Sala, Elisa
A1  - Giavoli, Claudia
A1  - Arosio, Maura
A1  - Lania, Andrea Gerardo
A1  - Ronchi, Christina Lucia
A1  - Mantovani, Giovanna
A1  - Beck-Peccoz, Paolo
A1  - Spada, Anna
T1  - Reevaluation of Acromegalic Patients in Long-Term Remission according to Newly Proposed Consensus Criteria for Control of Disease
JF  - International Journal of Endocrinology
N2  - Acromegaly guidelines updated in 2010 revisited criteria of disease control: if applied, it is likely that a percentage of patients previously considered as cured might present postglucose GH nadir levels not adequately suppressed, with potential implications on management. This study explored GH secretion, as well as hormonal, clinical, neuroradiological, metabolic, and comorbid profile in a cohort of 40 acromegalic patients considered cured on the basis of the previous guidelines after a mean follow-up period of 17.2 years from remission, in order to assess the impact of the current criteria. At the last follow-up visit, in the presence of normal IGF-I concentrations, postglucose GH nadir was over 0.4 mu g/L in 11 patients (Group A) and below 0.4 mu g/L in 29 patients (Group B); moreover, Group A showed higher basal GH levels than Group B, whereas a significant decline of both GH and postglucose GH nadir levels during the follow-up was observed in Group B only. No differences in other evaluated parameters were found. These results seem to suggest that acromegalic patients considered cured on the basis of previous guidelines do not need a more intensive monitoring than patients who met the current criteria of disease control, supporting instead that the cut-off of 0.4 mcg/L might be too low for the currently used GH assay.
KW  - IGF-I
KW  - glucose tolerance test
KW  - growth hormone deficiency
KW  - body mass index
KW  - oral glucose
KW  - GH response
KW  - mortality
KW  - immunoassays
KW  - statement
KW  - diagnosis
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-117790
SN  - 1687-8345
ER  -