TY  - JOUR
A1  - Freitag‐Wolf, Sandra
A1  - Munz, Matthias
A1  - Junge, Olaf
A1  - Graetz, Christian
A1  - Jockel‐Schneider, Yvonne
A1  - Staufenbiel, Ingmar
A1  - Bruckmann, Corinna
A1  - Lieb, Wolfgang
A1  - Franke, Andre
A1  - Loos, Bruno G.
A1  - Jepsen, Søren
A1  - Dommisch, Henrik
A1  - Schaefer, Arne S.
T1  - Sex‐specific genetic factors affect the risk of early‐onset periodontitis in Europeans
JF  - Journal of Clinical Periodontology
N2  - Aims
Various studies have reported that young European women are more likely to develop early‐onset periodontitis compared to men. A potential explanation for the observed variations in sex and age of disease onset is the natural genetic variation within the autosomal genomes. We hypothesized that genotype‐by‐sex (G × S) interactions contribute to the increased prevalence and severity.
Materials and methods
Using the case‐only design, we tested for differences in genetic effects between men and women in 896 North‐West European early‐onset cases, using imputed genotypes from the OmniExpress genotyping array. Population‐representative 6823 controls were used to verify that the interacting variables G and S were uncorrelated in the general population.
Results
In total, 20 loci indicated G × S associations (P < 0.0005), 3 of which were previously suggested as risk genes for periodontitis (ABLIM2, CDH13, and NELL1). We also found independent G × S interactions of the related gene paralogs MACROD1/FLRT1 (chr11) and MACROD2/FLRT3 (chr20). G × S‐associated SNPs at CPEB4, CDH13, MACROD1, and MECOM were genome‐wide‐associated with heel bone mineral density (CPEB4, MECOM), waist‐to‐hip ratio (CPEB4, MACROD1), and blood pressure (CPEB4, CDH13).
Conclusions
Our results indicate that natural genetic variation affects the different heritability of periodontitis among sexes and suggest genes that contribute to inter‐sex phenotypic variation in early‐onset periodontitis.
KW  - alveolar bone loss
KW  - gene × sex interaction
KW  - genetic risk
KW  - heritability
KW  - inflammation
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-262445
VL  - 48
IS  - 11
SP  - 1404
EP  - 1413
ER  - 
TY  - JOUR
A1  - Müller, Dominik
A1  - Graetz, Jonas
A1  - Balles, Andreas
A1  - Stier, Simon
A1  - Hanke, Randolf
A1  - Fella, Christian
T1  - Laboratory-Based Nano-Computed Tomography and Examples of Its Application in the Field of Materials Research
JF  - Crystals
N2  - In a comprehensive study, we demonstrate the performance and typical application scenarios for laboratory-based nano-computed tomography in materials research on various samples. Specifically, we focus on a projection magnification system with a nano focus source. The imaging resolution is quantified with common 2D test structures and validated in 3D applications by means of the Fourier Shell Correlation. As representative application examples from nowadays material research, we show metallization processes in multilayer integrated circuits, aging in lithium battery electrodes, and volumetric of metallic sub-micrometer fillers of composites. Thus, the laboratory system provides the unique possibility to image non-destructively structures in the range of 170–190 nanometers, even for high-density materials.
KW  - nano CT
KW  - laboratory
KW  - X-ray
KW  - 3D reconstruction
KW  - instrumentation
KW  - integrated circuits
KW  - nondestructive testing
KW  - 3D X-ray microscopy
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-241048
SN  - 2073-4352
VL  - 11
IS  - 6
ER  -