TY  - JOUR
A1  - Brosinsky, Paulin
A1  - Leister, Hanna
A1  - Cheng, Nan
A1  - Varelas, Xaralabos
A1  - Visekruna, Alexander
A1  - Luu, Maik
T1  - Verteporfin protects against Th17 cell‐mediated EAE independently of YAP inhibition
JF  - European Journal of Immunology
N2  - The known YAP inhibitor verteporfin is capable of repressing IL‐17A production in Th17 cells. However, this effect is mediated independently of YAP and can ameliorate Th17‐mediated experimental autoimmune encephalomyelitis (EAE) upon in vivo administration. The data suggest verteprofin's mode of action for the design of novel therapeutic autoimmune disease intervention.
KW  - Hippo signaling
KW  - YAP
KW  - verteporfin
KW  - Th17 cells
KW  - EAE
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-287234
VL  - 52
IS  - 9
SP  - 1523
EP  - 1526
ER  -