TY  - JOUR
A1  - Zahran, Eman Maher
A1  - Albohy, Amgad
A1  - Khalil, Amira
A1  - Ibrahim, Alyaa Hatem
A1  - Ahmed, Heba Ali
A1  - El-Hossary, Ebaa M.
A1  - Bringmann, Gerhard
A1  - Abdelmohsen, Usama Ramadan
T1  - Bioactivity Potential of Marine Natural Products from Scleractinia-Associated Microbes and In Silico Anti-SARS-COV-2 Evaluation
JF  - Marine Drugs
N2  - Marine organisms and their associated microbes are rich in diverse chemical leads. With the development of marine biotechnology, a considerable number of research activities are focused on marine bacteria and fungi-derived bioactive compounds. Marine bacteria and fungi are ranked on the top of the hierarchy of all organisms, as they are responsible for producing a wide range of bioactive secondary metabolites with possible pharmaceutical applications. Thus, they have the potential to provide future drugs against challenging diseases, such as cancer, a range of viral diseases, malaria, and inflammation. This review aims at describing the literature on secondary metabolites that have been obtained from Scleractinian-associated organisms including bacteria, fungi, and zooxanthellae, with full coverage of the period from 1982 to 2020, as well as illustrating their biological activities and structure activity relationship (SAR). Moreover, all these compounds were filtered based on ADME analysis to determine their physicochemical properties, and 15 compounds were selected. The selected compounds were virtually investigated for potential inhibition for SARS-CoV-2 targets using molecular docking studies. Promising potential results against SARS-CoV-2 RNA dependent RNA polymerase (RdRp) and methyltransferase (nsp16) are presented.
KW  - Scleractinia
KW  - marine bacteria
KW  - marine fungi
KW  - zooxanthellae
KW  - marine natural products
KW  - ADME analysis
KW  - SARS-CoV-2
KW  - molecular docking
KW  - RNA-dependent RNA polymerase
KW  - methyltransferase
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-220041
SN  - 1660-3397
VL  - 18
IS  - 12
ER  -