TY  - JOUR
A1  - Estrada, Veronica
A1  - Krebbers, Julia
A1  - Voss, Christian
A1  - Brazda, Nicole
A1  - Blazyca, Heinrich
A1  - Illgen, Jennifer
A1  - Seide, Klaus
A1  - Jürgens, Christian
A1  - Müller, Jörg
A1  - Martini, Rudolf
A1  - Trieu, Hoc Khiem
A1  - Müller, Hans Werner
T1  - Low-pressure micro-mechanical re-adaptation device sustainably and effectively improves locomotor recovery from complete spinal cord injury
JF  - Communications Biology
N2  - Traumatic spinal cord injuries result in impairment or even complete loss of motor, sensory and autonomic functions. Recovery after complete spinal cord injury is very limited even in animal models receiving elaborate combinatorial treatments. Recently, we described an implantable microsystem (microconnector) for low-pressure re-adaption of severed spinal stumps in rat. Here we investigate the long-term structural and functional outcome following microconnector implantation after complete spinal cord transection. Re-adaptation of spinal stumps supports formation of a tissue bridge, glial and vascular cell invasion, motor axon regeneration and myelination, resulting in partial recovery of motor-evoked potentials and a thus far unmet improvement of locomotor behaviour. The recovery lasts for at least 5 months. Despite a late partial decline, motor recovery remains significantly superior to controls. Our findings demonstrate that microsystem technology can foster long-lasting functional improvement after complete spinal injury, providing a new and effective tool for combinatorial therapies.
KW  - implants
KW  - preclinical research
KW  - spinal cord injury
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227357
VL  - 1
ER  - 
TY  - JOUR
A1  - Christl, Manfred
A1  - Leß, Roland
A1  - Müller, Heinrich
T1  - 6,7-Dimethylene-2,4-diphenylbicyclo[3.2.l]oct-3-en-2-yl Anion : A Test for the Origin of the Unusual Properties of the Bicyclo[3.2.l]octa-3,6-dien-2-yl Anion
N2  - No abstract available
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31547
ER  - 
TY  - JOUR
A1  - Richter, Julia
A1  - Hüttmann, Andreas
A1  - Rekowski, Jan
A1  - Schmitz, Christine
A1  - Gärtner, Selina
A1  - Rosenwald, Andreas
A1  - Hansmann, Martin-Leo
A1  - Hartmann, Sylvia
A1  - Möller, Peter
A1  - Wacker, Hans-Heinrich
A1  - Feller, Alfred
A1  - Thorns, Christoph
A1  - Müller, Stefan
A1  - Dührsen, Ulrich
A1  - Klapper, Wolfram
T1  - Molecular characteristics of diffuse large B-cell lymphoma in the Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin lymphomas (PETAL) trial: correlation with interim PET and outcome
JF  - Blood Cancer Journal
N2  - No abstract available
KW  - Cancer genetics
KW  - Medical research
KW  - Translational research
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226185
VL  - 9
ER  -