TY  - JOUR
A1  - Megas, Ioannis-Fivos
A1  - Simons, David
A1  - Kim, Bong-Sung
A1  - Stoppe, Christian
A1  - Piatkowski, Andrzej
A1  - Fikatas, Panagiotis
A1  - Fuchs, Paul Christian
A1  - Bastiaanse, Jacqueline
A1  - Pallua, Norbert
A1  - Bernhagen, Jürgen
A1  - Grieb, Gerrit
T1  - Macrophage migration inhibitory factor — an innovative indicator for free flap ischemia after microsurgical reconstruction
JF  - Healthcare
N2  - (1) Background: Nowadays, the use of microsurgical free flaps is a standard operative procedure in reconstructive surgery. Still, thrombosis of the microanastomosis is one of the most fatal postoperative complications. Clinical evaluation, different technical devices and laboratory markers are used to monitor critical flap perfusion. Macrophage migration inhibitory factor (MIF), a structurally unique cytokine with chemokine-like characteristics, could play a role in predicting vascular problems and the failure of flap perfusion. (2) Methods: In this prospective observational study, 26 subjects that underwent microsurgical reconstruction were observed. Besides clinical data, the number of blood leukocytes, CRP and MIF were monitored. (3) Results: Blood levels of MIF, C-reactive protein (CRP) and leukocytes increased directly after surgery. Subjects that needed surgical revision due to thrombosis of the microanastomosis showed significantly higher blood levels of MIF than subjects without revision. (4) Conclusion: We conclude that MIF is a potential and innovative indicator for thrombosis of the microanastomosis after free flap surgery. Since it is easy to obtain diagnostically, MIF could be an additional tool to monitor flap perfusion besides clinical and technical assessments.
KW  - macrophage migration inhibitory factor (MIF)
KW  - free flap surgery
KW  - innovative surgical methods
KW  - microanastomosis
KW  - ischemia
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-239632
SN  - 2227-9032
VL  - 9
IS  - 6
ER  -