TY  - JOUR
A1  - Teles, Ramon Handerson Gomes
A1  - Yano, Rafael Sussumu
A1  - Villarinho, Nicolas Jones
A1  - Yamagata, Ana Sayuri
A1  - Jaeger, Ruy Gastaldoni
A1  - Meybohm, Patrick
A1  - Burek, Malgorzata
A1  - Freitas, Vanessa Morais
T1  - Advances in breast cancer management and extracellular vesicle research, a bibliometric analysis
JF  - Current Oncology
N2  - Extracellular vesicles transport variable content and have crucial functions in cell–cell communication. The role of extracellular vesicles in cancer is a current hot topic, and no bibliometric study has ever analyzed research production regarding their role in breast cancer and indicated the trends in the field. In this way, we aimed to investigate the trends in breast cancer management involved with extracellular vesicle research. Articles were retrieved from Scopus, including all the documents published concerning breast cancer and extracellular vesicles. We analyzed authors, journals, citations, affiliations, and keywords, besides other bibliometric analyses, using R Studio version 3.6.2. and VOSviewer version 1.6.0. A total of 1151 articles were retrieved, and as the main result, our analysis revealed trending topics on biomarkers of liquid biopsy, drug delivery, chemotherapy, autophagy, and microRNA. Additionally, research related to extracellular vesicles in breast cancer has been focused on diagnosis, treatment, and mechanisms of action of breast tumor-derived vesicles. Future studies are expected to explore the role of extracellular vesicles on autophagy and microRNA, besides investigating the application of extracellular vesicles from liquid biopsies for biomarkers and drug delivery, enabling the development and validation of therapeutic strategies for specific cancers.
KW  - breast cancer
KW  - metastasis
KW  - exosomes
KW  - extracellular vesicles
KW  - bibliometrics
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-284321
SN  - 1718-7729
VL  - 28
IS  - 6
SP  - 4504
EP  - 4520
ER  -