TY  - JOUR
A1  - Rullmann, Michael
A1  - Preusser, Sven
A1  - Poppitz, Sindy
A1  - Heba, Stefanie
A1  - Gousias, Konstantinos
A1  - Hoyer, Jana
A1  - Schütz, Tatjana
A1  - Dietrich, Arne
A1  - Müller, Karsten
A1  - Hankir, Mohammed K.
A1  - Pleger, Burkhard
T1  - Adiposity Related Brain Plasticity Induced by Bariatric Surgery
JF  - Froniers in Human Neuroscience
N2  - Previous magnetic resonance imaging (MRI) studies revealed structural-functional brain reorganization 12 months after gastric-bypass surgery, encompassing cortical and subcortical regions of all brain lobes as well as the cerebellum. Changes in the mean of cluster-wise gray/white matter density (GMD/WMD) were correlated with the individual loss of body mass index (BMI), rendering the BMI a potential marker of widespread surgery-induced brain plasticity. Here, we investigated voxel-by-voxel associations between surgery-induced changes in adiposity, metabolism and inflammation and markers of functional and structural neural plasticity. We re-visited the data of patients who underwent functional and structural MRI, 6 months (n = 27) and 12 months after surgery (n = 22), and computed voxel-wise regression analyses. Only the surgery-induced weight loss was significantly associated with brain plasticity, and this only for GMD changes. After 6 months, weight loss overlapped with altered GMD in the hypothalamus, the brain's homeostatic control site, the lateral orbitofrontal cortex, assumed to host reward and gustatory processes, as well as abdominal representations in somatosensory cortex. After 12 months, weight loss scaled with GMD changes in right cerebellar lobule VII, involved in language-related/cognitive processes, and, by trend, with the striatum, assumed to underpin (food) reward. These findings suggest time-dependent and weight-loss related gray matter plasticity in brain regions involved in the control of eating, sensory processing and cognitive functioning.
KW  - adiposity
KW  - magnetic resonance imaging
KW  - brain plasticity
KW  - bariatric surgery
KW  - gastric-bypass surgery
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227168
VL  - 13
ER  -