TY  - JOUR
A1  - Ma, Eric Yue
A1  - Calvo, M. Reyes
A1  - Wang, Jing
A1  - Lian, Biao
A1  - Mühlbauer, Mathias
A1  - Brüne, Christoph
A1  - Cui, Yong-Tao
A1  - Lai, Keji
A1  - Kundhikanjana, Worasom
A1  - Yang, Yongliang
A1  - Baenninger, Matthias
A1  - König, Markus
A1  - Ames, Christopher
A1  - Buhmann, Hartmut
A1  - Leubner, Philipp
A1  - Molenkamp, Laurens W.
A1  - Zhang, Shou-Cheng
A1  - Goldhaber-Gordon, David
A1  - Kelly, Michael A.
A1  - Shen, Zhi-Xun
T1  - Unexpected edge conduction in mercury telluride quantum wells under broken time-reversal symmetry
JF  - Nature Communications
N2  - The realization of quantum spin Hall effect in HgTe quantum wells is considered a milestone in the discovery of topological insulators. Quantum spin Hall states are predicted to allow current flow at the edges of an insulating bulk, as demonstrated in various experiments. A key prediction yet to be experimentally verified is the breakdown of the edge conduction under broken time-reversal symmetry. Here we first establish a systematic framework for the magnetic field dependence of electrostatically gated quantum spin Hall devices. We then study edge conduction of an inverted quantum well device under broken time-reversal symmetry using microwave impedance microscopy, and compare our findings to a noninverted device. At zero magnetic field, only the inverted device shows clear edge conduction in its local conductivity profile, consistent with theory. Surprisingly, the edge conduction persists up to 9 T with little change. This indicates physics beyond simple quantum spin Hall model, including material-specific properties and possibly many-body effects.
KW  - topological insulators
KW  - surface states
KW  - HgTe
KW  - Hg1-xCdxTe
KW  - vacancies
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-143185
VL  - 6
IS  - 7252
ER  - 
TY  - JOUR
A1  - Deane, Katrina E.
A1  - Brunk, Michael G. K.
A1  - Curran, Andrew W.
A1  - Zempeltzi, Marina M.
A1  - Ma, Jing
A1  - Lin, Xiao
A1  - Abela, Francesca
A1  - Aksit, Sümeyra
A1  - Deliano, Matthias
A1  - Ohl, Frank W.
A1  - Happel, Max F. K.
T1  - Ketamine anaesthesia induces gain enhancement via recurrent excitation in granular input layers of the auditory cortex
JF  - The Journal of Physiology
N2  - Ketamine is commonly used as an anaesthetic agent and has more recently gained attention as an antidepressant. It has been linked to increased stimulus‐locked excitability, inhibition of interneurons and modulation of intrinsic neuronal oscillations. However, the functional network mechanisms are still elusive. A better understanding of these anaesthetic network effects may improve upon previous interpretations of seminal studies conducted under anaesthesia and have widespread relevance for neuroscience with awake and anaesthetized subjects as well as in medicine. Here, we investigated the effects of anaesthetic doses of ketamine (15 mg kg\(^{-1}\) h\(^{-1}\)i.p.) on the network activity after pure‐tone stimulation within the auditory cortex of male Mongolian gerbils (Meriones unguiculatus). We used laminar current source density (CSD) analysis and subsequent layer‐specific continuous wavelet analysis to investigate spatiotemporal response dynamics on cortical columnar processing in awake and ketamine‐anaesthetized animals. We found thalamocortical input processing within granular layers III/IV to be significantly increased under ketamine. This layer‐dependent gain enhancement under ketamine was not due to changes in cross‐trial phase coherence but was rather attributed to a broadband increase in magnitude reflecting an increase in recurrent excitation. A time–frequency analysis was indicative of a prolonged period of stimulus‐induced excitation possibly due to a reduced coupling of excitation and inhibition in granular input circuits – in line with the common hypothesis of cortical disinhibition via suppression of GABAergic interneurons.
KW  - auditory cortex
KW  - continuous wavelet analysis
KW  - current source density
KW  - ketamine anaesthesia
KW  - laminar recording
KW  - mesoscopic
KW  - microcircuitry
KW  - population dynamics
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-216123
VL  - 598
IS  - 13
SP  - 2741
EP  - 2755
ER  -