TY - THES A1 - Joachim, Silvia T1 - Regulatorketten in Butlergruppen T1 - Regulator Chains of Butler Groups N2 - Die fast vollständig zerlegbaren Gruppen bilden eine Teilklasse der Butlergruppen. Das Konzept des Regulators, d.h. der Durchschnitt aller regulierenden Untergruppen, ist unverzichtbar für fast vollständig zerlegbare Gruppen. Dieses Konzept lässt sich in natürlicher Weise auf die ganze Klasse der Butlergruppen fortsetzen. Allerdings lässt sich die Regulatorbildung im allgemeineren Fall der Butlergruppen a priori iterieren. Damit stellt sich erst einmal die Frage, ob es überhaupt Butlergruppen gibt mit Regulatorketten, der Länge größer als 1. Ein erstes Beispiel der Länge 2 wurde 1997 von Lehrmann und Mutzbauer konstruiert. In dieser Dissertation wurden mit konzeptionell neuen Techniken Butlergruppen mit beliebiger vorgegebener endlicher Kettenlänge angegeben. Grundsätzliche Schwierigkeiten bei diesem Unterfangen resultieren aus dem Fehlen, bzw. der Unmöglichkeit, einer kanonischen Darstellung von Butlergruppen. Man verwendet die allseits gebrauchte Summendarstellung für Butlergruppen. Genau an dieser Stelle bedarf es völlig neuer Methoden, verglichen mit den fast vollständig zerlegbaren Gruppen mit ihrer kanonischen Regulatordarstellung. Alle Teilaufgaben bei der anstehenden Konstruktion von Butlergruppen, die für fast vollständig zerlegbare Gruppen Standard sind, werden hierbei problematisch, u.a. die Bildung reiner Hüllen, die Bestimmung regulierender Untergruppen und die Regulatorbildung. N2 - The almost completely decomposable groups form a subclass of the Butler groups. The concept of a regulator, i. e., the intersection of all regulating subgroups, is inevitable for almost completely decomposable groups. This concept can be transferred and continued to the whole class of Butler groups in a natural way. However, forming the regulator for Butler groups usually allows proper iteration. Thus, the primary question is, if there are any Butler groups at all with longer regulator chains, the length longer than 1. A first example of length 2 was constructed by Lehrmann and Mutzbauer in 1997. In this doctoral dissertation Butler groups were constructed of an arbitrarily given finite chain length, using conceptually new techniques. Basic difficulties resulted from the lack, or respectively, the impossibility, of any canonical descriptions of Butler groups. Usually Butler groups are given by the so called sum representation. Precisely here completely new methods are necessary to be applied, compared with the almost completely decomposable groups and their canonical regulator representation. All detailed tasks for the indicated construction of Butler groups, which are standard for almost completely decomposable groups, become problematic, among other things the forming of pure hulls, the determination of regulating subgroups, and the construction of the regulator. KW - Butlergruppe KW - Regulator KW - Butlergruppe KW - regulierende Untergruppen KW - Regulator KW - Butler group KW - regulating subgroup KW - regulator Y1 - 2004 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-10438 ER - TY - JOUR A1 - Sperlich, Billy A1 - Achtzehn, Silvia A1 - de Marées, Markus A1 - von Papen, Henning A1 - Mester, Joachim T1 - Load management in elite German distance runners during 3-weeks of high-altitude training JF - Physiological Reports N2 - There is a debate on the optimal way of monitoring training loads in elite endurance athletes especially during altitude training camps. In this case report, including nine members of the German national middle distance running team, we describe a practical approach to monitor the psychobiological stress markers during 21 days of altitude training (~2100 m above sea‐level) to estimate the training load and to control muscle damage, fatigue, and/or chronic overreaching. Daily examination included: oxygen saturation of hemoglobin, resting heart rate, body mass, body and sleep perception, capillary blood concentration of creatine kinase. Every other day, venous serum concentration of blood urea nitrogen, venous blood concentration of hemoglobin, hematocrit, red and white blood cell were measured. If two or more of the above‐mentioned stress markers were beyond or beneath the athlete's normal individual range, the training load of the subsequent training session was reduced. Running speed at 3 mmol L\(^{−1}\) blood lactate (V\(_{3}\)) improved and no athlete showed any signs of underperformance, chronic muscle damage, decrease body and sleep perception as well as activated inflammatory process during the 21 days. The dense screening of biomarkers in the present case study may stimulate further research to identify candidate markers for load monitoring in elite middle‐ and long‐distance runners during a training camp at altitude. KW - distance running KW - training load KW - stress markers KW - biomarkers KW - high-altitude training Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-171294 VL - 4 IS - 12 ER - TY - JOUR A1 - Han, Chao A1 - Ren, Pengxuan A1 - Mamtimin, Medina A1 - Kruk, Linus A1 - Sarukhanyan, Edita A1 - Li, Chenyu A1 - Anders, Hans-Joachim A1 - Dandekar, Thomas A1 - Krueger, Irena A1 - Elvers, Margitta A1 - Goebel, Silvia A1 - Adler, Kristin A1 - Münch, Götz A1 - Gudermann, Thomas A1 - Braun, Attila A1 - Mammadova-Bach, Elmina T1 - Minimal collagen-binding epitope of glycoprotein VI in human and mouse platelets JF - Biomedicines N2 - Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen and fibrin, regulating important platelet functions such as platelet adhesion and thrombus growth. Although the blockade of GPVI function is widely recognized as a potent anti-thrombotic approach, there are limited studies focused on site-specific targeting of GPVI. Using computational modeling and bioinformatics, we analyzed collagen- and CRP-binding surfaces of GPVI monomers and dimers, and compared the interacting surfaces with other mammalian GPVI isoforms. We could predict a minimal collagen-binding epitope of GPVI dimer and designed an EA-20 antibody that recognizes a linear epitope of this surface. Using platelets and whole blood samples donated from wild-type and humanized GPVI transgenic mice and also humans, our experimental results show that the EA-20 antibody inhibits platelet adhesion and aggregation in response to collagen and CRP, but not to fibrin. The EA-20 antibody also prevents thrombus formation in whole blood, on the collagen-coated surface, in arterial flow conditions. We also show that EA-20 does not influence GPVI clustering or receptor shedding. Therefore, we propose that blockade of this minimal collagen-binding epitope of GPVI with the EA-20 antibody could represent a new anti-thrombotic approach by inhibiting specific interactions between GPVI and the collagen matrix. KW - GPVI KW - collagen KW - blood platelets KW - thrombosis KW - anti-thrombotic therapies Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-304148 SN - 2227-9059 VL - 11 IS - 2 ER -