TY  - JOUR
A1  - Jansen, Nils
A1  - Ohlendorf, Birgit
A1  - Erhard, Arlette
A1  - Bruhn, Torsten
A1  - Bringmann, Gerhard
A1  - Imhoff, Johannes F.
T1  - Helicusin E, Isochromophilone X and Isochromophilone XI: New Chloroazaphilones Produced by the Fungus Bartalinia robillardoides Strain LF550
JF  - Marine Drugs
N2  - Microbial studies of the Mediterranean sponge Tethya aurantium led to the isolation of the fungus Bartalinia robillardoides strain LF550. The strain produced a number of secondary metabolites belonging to the chloroazaphilones. This is the first report on the isolation of chloroazaphilones of a fungal strain belonging to the genus Bartalinia. Besides some known compounds (helicusin A (1) and deacetylsclerotiorin (2)), three new chloroazaphilones (helicusin E (3); isochromophilone X (4) and isochromophilone XI (5)) and one new pentaketide (bartanolide (6)) were isolated. The structure elucidations were based on spectroscopic analyses. All isolated compounds revealed different biological activity spectra against a test panel of four bacteria: three fungi; two tumor cell lines and two enzymes.
KW  - tethya aurantium
KW  - marine natural product
KW  - azaphilone
KW  - pentaketide
KW  - bartalinia robillardoides
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-129649
VL  - 11
IS  - 3
ER  -