TY  - JOUR
A1  - Katzorke, Andrea
A1  - Zeller, Julia B. M.
A1  - Müller, Laura D.
A1  - Lauer, Martin
A1  - Polak, Thomas
A1  - Reif, Andreas
A1  - Deckert, Jürgen
A1  - Herrmann, Martin J.
T1  - Reduced activity in the right inferior frontal gyrus in elderly APOE-E4 carriers during a verbal fluency task
JF  - Frontiers in Human Neuroscience
N2  - Apolipoprotein-E4 (APOE-E4) is a major genetic risk factor for developing Alzheimer’s disease (AD). The verbal fluency task (VFT), especially the subtask category fluency, has shown to provide a good discrimination between cognitively normal controls and subjects with AD. Interestingly, APOE-E4 seems to have no effect on the behavioral performance during a VFT in healthy elderly. Thus, the purpose of the present study was to reveal possible compensation mechanisms by investigating the effect of APOE-E4 on the hemodynamic response in non-demented elderly during a VFT by using functional near-infrared spectroscopy (fNIRS). We compared performance and hemodynamic response of high risk APOE-E4/E4, -E3/E4 carriers with neutral APOE-E3/E3 non-demented subjects (N = 288; 70–77 years). No difference in performance was found. APOE-E4/E4, -E3/E4 carriers had a decreased hemodynamic response in the right inferior frontal junction (IFJ) with a corresponding higher response in the left middle frontal gyrus (MFG) during category fluency. Performance was correlated with the hemodynamic response in the MFG. We assume a compensation of decreased IFJ brain activation by utilizing the MFG during category fluency and thus resulting in no behavioral differences between APOE-groups during the performance of a VFT.
KW  - psychiatry
KW  - near-infrared spectroscopy
KW  - verbal fluency task
KW  - apolipoprotein-E4
KW  - Alzheimer's disease
KW  - elderly
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-171892
VL  - 11
ER  - 
TY  - JOUR
A1  - Kobsar, Anna
A1  - Koehnlechner, Karina
A1  - Klingler, Philipp
A1  - Niklaus, Marius
A1  - Zeller-Hahn, Julia
A1  - Koessler, Angela
A1  - Weber, Katja
A1  - Boeck, Markus
A1  - Koessler, Juergen
T1  - The effect of short-term refrigeration on platelet responsiveness
JF  - Scientific Reports
N2  - Storage of platelet concentrates (PC) at cold temperature (CT) is discussed as an alternative to the current standard of storage at room temperature (RT). Recently, we could show that cold-induced attenuation of inhibitory signaling is an important mechanism promoting platelet reactivity. For developing strategies in blood banking, it is required to elucidate the time-dependent onset of facilitated platelet activation. Thus, freshly prepared platelet-rich-plasma (PRP) was stored for 1 and 2 h at CT (2–6 °C) or at RT (20–24 °C), followed by subsequent comparative analysis. Compared to RT, basal and induced vasodilator-stimulated phosphoprotein (VASP) phosphorylation levels were decreased under CT within 1 h by approximately 20%, determined by Western blot analysis and flow cytometry. Concomitantly, ADP- and collagen-induced threshold aggregation values were enhanced by up to 30–40%. Furthermore, platelet-covered areas on collagen-coated slides and aggregate formation under flow conditions were increased after storage at CT, in addition to induced activation markers. In conclusion, a time period of 1–2 h for refrigeration is sufficient to induce an attenuation of inhibitory signaling, accompanied with an enhancement of platelet responsiveness. Short-term refrigeration may be considered as a rational approach to obtain PC with higher functional reactivity for the treatment of hemorrhage.
KW  - short‑term refrigeration
KW  - platelet responsiveness
KW  - cold temperature
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-301390
VL  - 12
IS  - 1
ER  -