TY - INPR A1 - Böhnke, Julian A1 - Dellermann, Theresa A1 - Celik, Mehmet Ali A1 - Krummenacher, Ivo A1 - Dewhurst, Rian D. A1 - Demeshko, Serhiy A1 - Ewing, William C. A1 - Hammond, Kai A1 - Heß, Merlin A1 - Bill, Eckhard A1 - Welz, Eileen A1 - Röhr, Merle I. S. A1 - Mitric, Roland A1 - Engels, Bernd A1 - Meyer, Franc A1 - Braunschweig, Holger T1 - Isolation of diradical products of twisted double bonds T2 - Nature Communications N2 - Molecules containing multiple bonds between atoms—most often in the form of olefins—are ubiquitous in nature, commerce, and science, and as such have a huge impact on everyday life. Given their prominence, over the last few decades, frequent attempts have been made to perturb the structure and reactivity of multiply-bound species through bending and twisting. However, only modest success has been achieved in the quest to completely twist double bonds in order to homolytically cleave the associated π bond. Here, we present the isolation of double-bond-containing species based on boron, as well as their fully twisted diradical congeners, by the incorporation of attached groups with different electronic properties. The compounds comprise a structurally authenticated set of diamagnetic multiply-bound and diradical singly-bound congeners of the same class of compound. KW - diradicals KW - diborenes KW - carbenes KW - boron Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-160248 N1 - Submitted version of Julian Böhnke, Theresa Dellermann, Mehmet Ali Celik, Ivo Krummenacher, Rian D. Dewhurst, Serhiy Demeshko, William C. Ewing, Kai Hammond, Merlin Heß, Eckhard Bill, Eileen Welz, Merle I. S. Röhr, Roland Mitrić, Bernd Engels, Franc Meyer & Holger Braunschweig: Isolation of diborenes and their 90°-twisted diradical congeners. Nature Communications. Volume 9, Article number: 1197 (2018) doi:10.1038/s41467-018-02998-3 ER - TY - JOUR A1 - Dupuis, Luc A1 - Dengler, Reinhard A1 - Heneka, Michael T. A1 - Meyer, Thomas A1 - Zierz, Stephan A1 - Kassubek, Jan A1 - Fischer, Wilhelm A1 - Steiner, Franziska A1 - Lindauer, Eva A1 - Otto, Markus A1 - Dreyhaupt, Jens A1 - Grehl, Torsten A1 - Hermann, Andreas A1 - Winkler, Andrea S. A1 - Bogdahn, Ulrich A1 - Benecke, Reiner A1 - Schrank, Bertold A1 - Wessig, Carsten A1 - Grosskreutz, Julian A1 - Ludolph, Albert C. T1 - A Randomized, Double Blind, Placebo-Controlled Trial of Pioglitazone in Combination with Riluzole in Amyotrophic Lateral Sclerosis JF - PLoS One N2 - Background: Pioglitazone, an oral anti-diabetic that stimulates the PPAR-gamma transcription factor, increased survival of mice with amyotrophic lateral sclerosis (ALS). Methods/Principal Findings: We performed a phase II, double blind, multicentre, placebo controlled trial of pioglitazone in ALS patients under riluzole. 219 patients were randomly assigned to receive 45 mg/day of pioglitazone or placebo (one: one allocation ratio). The primary endpoint was survival. Secondary endpoints included incidence of non-invasive ventilation and tracheotomy, and slopes of ALS-FRS, slow vital capacity, and quality of life as assessed using EUROQoL EQ-5D. The study was conducted under a two-stage group sequential test, allowing to stop for futility or superiority after interim analysis. Shortly after interim analysis, 30 patients under pioglitazone and 24 patients under placebo had died. The trial was stopped for futility; the hazard ratio for primary endpoint was 1.21 (95% CI: 0.71-2.07, p = 0.48). Secondary endpoints were not modified by pioglitazone treatment. Pioglitazone was well tolerated. Conclusion/Significance: Pioglitazone has no beneficial effects on the survival of ALS patients as add-on therapy to riluzole. KW - ALS KW - transgenic mouse model KW - central nervous system KW - nonalcoholic steatohepatitis KW - PPAR-gamme KW - hexanucleotide repeat KW - disease progression KW - delays progression KW - SOD1 mutations KW - monocycline Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-130255 VL - 7 IS - 6 ER - TY - JOUR A1 - Böhnke, Julian A1 - Dellermann, Theresa A1 - Celik, Mehmet Ali A1 - Krummenacher, Ivo A1 - Dewhurst, Rian D. A1 - Demeshko, Serhiy A1 - Ewing, William C. A1 - Hammond, Kai A1 - Heß, Merlin A1 - Bill, Eckhard A1 - Welz, Eileen A1 - Röhr, Merle I. S. A1 - Mitric, Roland A1 - Engels, Bernd A1 - Meyer, Franc A1 - Braunschweig, Holger T1 - Isolation of diborenes and their 90°-twisted diradical congeners JF - Nature Communications N2 - Molecules containing multiple bonds between atoms—most often in the form of olefins—are ubiquitous in nature, commerce, and science, and as such have a huge impact on everyday life. Given their prominence, over the last few decades, frequent attempts have been made to perturb the structure and reactivity of multiply-bound species through bending and twisting. However, only modest success has been achieved in the quest to completely twist double bonds in order to homolytically cleave the associated π bond. Here, we present the isolation of double-bond-containing species based on boron, as well as their fully twisted diradical congeners, by the incorporation of attached groups with different electronic properties. The compounds comprise a structurally authenticated set of diamagnetic multiply-bound and diradical singly-bound congeners of the same class of compound. KW - chemical bonding KW - diradicals KW - organometallic chemistry KW - diborenes KW - carbenes KW - boron Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-160431 VL - 9 IS - Article number: 1197 ER - TY - JOUR A1 - Dindas, Julian A1 - Scherzer, Sönke A1 - Roelfsema, M. Rob G. A1 - Meyer, Katharina von A1 - Müller, Heike M. A1 - Al-Rasheid, K. A. S. A1 - Palme, Klaus A1 - Dietrich, Petra A1 - Becker, Dirk A1 - Bennett, Malcolm J. A1 - Hedrich, Rainer T1 - AUX1-mediated root hair auxin influx governs SCFTIR1/AFB-type Ca2+ signaling JF - Nature Communications N2 - Auxin is a key regulator of plant growth and development, but the causal relationship between hormone transport and root responses remains unresolved. Here we describe auxin uptake, together with early steps in signaling, in Arabidopsis root hairs. Using intracellular microelectrodes we show membrane depolarization, in response to IAA in a concentration- and pH-dependent manner. This depolarization is strongly impaired in aux1 mutants, indicating that AUX1 is the major transporter for auxin uptake in root hairs. Local intracellular auxin application triggers Ca2+ signals that propagate as long-distance waves between root cells and modulate their auxin responses. AUX1-mediated IAA transport, as well as IAA- triggered calcium signals, are blocked by treatment with the SCFTIR1/AFB - inhibitor auxinole. Further, they are strongly reduced in the tir1afb2afb3 and the cngc14 mutant. Our study reveals that the AUX1 transporter, the SCFTIR1/AFB receptor and the CNGC14 Ca2+ channel, mediate fast auxin signaling in roots. KW - auxin KW - permeation and transport Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-225368 VL - 9 ER - TY - JOUR A1 - Meyer, Julian S. A1 - Hessenauer, Florian M. A1 - Reichel, Thomas A1 - Pham, Mirko A1 - Plumhoff, Piet A1 - Rueckl, Kilian T1 - Isolated mononeuropathy of the suprascapular nerve: traumatic traction injury as an important differential diagnosis to the entrapment syndrome JF - JSES International N2 - No abstract available. KW - MR neurography KW - Suprascapular nerve KW - compression syndrome KW - neuropathy KW - shoulder neurolysis KW - suprascapular notch Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-229322 VL - 4 IS - 3 ER -