TY  - JOUR
A1  - Tuca, Alexandru-Cristian
A1  - Bernardelli de Mattos, Ives
A1  - Funk, Martin
A1  - Winter, Raimund
A1  - Palackic, Alen
A1  - Groeber-Becker, Florian
A1  - Kruse, Daniel
A1  - Kukla, Fabian
A1  - Lemarchand, Thomas
A1  - Kamolz, Lars-Peter
T1  - Orchestrating the dermal/epidermal tissue ratio during wound healing by controlling the moisture content
JF  - Biomedicines
N2  - A balanced and moist wound environment and surface increases the effect of various growth factors, cytokines, and chemokines, stimulating cell growth and wound healing. Considering this fact, we tested in vitro and in vivo water evaporation rates from the cellulose dressing epicite\(^{hydro}\) when combined with different secondary dressings as well as the resulting wound healing efficacy in a porcine donor site model. The aim of this study was to evaluate how the different rates of water evaporation affected wound healing efficacy. To this end, epicite\(^{hydro}\) primary dressing, in combination with different secondary dressing materials (cotton gauze, JELONET\(^◊\), AQUACEL\(^®\) Extra\(^™\), and OPSITE\(^◊\) Flexifix), was placed on 3 × 3 cm-sized dermatome wounds with a depth of 1.2 mm on the flanks of domestic pigs. The healing process was analyzed histologically and quantified by morphometry. High water evaporation rates by using the correct secondary dressing, such as cotton gauze, favored a better re-epithelialization in comparison with the low water evaporation resulting from an occlusive secondary dressing, which favored the formation of a new and intact dermal tissue that nearly fully replaced all the dermis that was removed during wounding. This newly available evidence may be of great benefit to clinical wound management.
KW  - bacterial cellulose dressing
KW  - secondary wound dressing
KW  - moisture balance
KW  - wound healing
KW  - in vivo experiments
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-275115
SN  - 2227-9059
VL  - 10
IS  - 6
ER  -