TY  - JOUR
A1  - Galluzzi, L.
A1  - Bravo-San Pedro, J. M.
A1  - Vitale, I.
A1  - Aaronson, S. A.
A1  - Abrams, J. M.
A1  - Adam, D.
A1  - Alnemri, E. S.
A1  - Altucci, L.
A1  - Andrews, D.
A1  - Annicchiarico-Petruzelli, M.
A1  - Baehrecke, E. H.
A1  - Bazan, N. G.
A1  - Bertrand, M. J.
A1  - Bianchi, K.
A1  - Blagosklonny, M. V.
A1  - Blomgren, K.
A1  - Borner, C.
A1  - Bredesen, D. E.
A1  - Brenner, C.
A1  - Campanella, M.
A1  - Candi, E.
A1  - Cecconi, F.
A1  - Chan, F. K.
A1  - Chandel, N. S.
A1  - Cheng, E. H.
A1  - Chipuk, J. E.
A1  - Cidlowski, J. A.
A1  - Ciechanover, A.
A1  - Dawson, T. M.
A1  - Dawson, V. L.
A1  - De Laurenzi, V.
A1  - De Maria, R.
A1  - Debatin, K. M.
A1  - Di Daniele, N.
A1  - Dixit, V. M.
A1  - Dynlacht, B. D.
A1  - El-Deiry, W. S.
A1  - Fimia, G. M.
A1  - Flavell, R. A.
A1  - Fulda, S.
A1  - Garrido, C.
A1  - Gougeon, M. L.
A1  - Green, D. R.
A1  - Gronemeyer, H.
A1  - Hajnoczky, G.
A1  - Hardwick, J. M.
A1  - Hengartner, M. O.
A1  - Ichijo, H.
A1  - Joseph, B.
A1  - Jost, P. J.
A1  - Kaufmann, T.
A1  - Kepp, O.
A1  - Klionsky, D. J.
A1  - Knight, R. A.
A1  - Kumar, S.
A1  - Lemasters, J. J.
A1  - Levine, B.
A1  - Linkermann, A.
A1  - Lipton, S. A.
A1  - Lockshin, R. A.
A1  - López-Otín, C.
A1  - Lugli, E.
A1  - Madeo, F.
A1  - Malorni, W.
A1  - Marine, J. C.
A1  - Martin, S. J.
A1  - Martinou, J. C.
A1  - Medema, J. P.
A1  - Meier, P.
A1  - Melino, S.
A1  - Mizushima, N.
A1  - Moll, U.
A1  - Muñoz-Pinedo, C.
A1  - Nuñez, G.
A1  - Oberst, A.
A1  - Panaretakis, T.
A1  - Penninger, J. M.
A1  - Peter, M. E.
A1  - Piacentini, M.
A1  - Pinton, P.
A1  - Prehn, J. H.
A1  - Puthalakath, H.
A1  - Rabinovich, G. A.
A1  - Ravichandran, K. S.
A1  - Rizzuto, R.
A1  - Rodrigues, C. M.
A1  - Rubinsztein, D. C.
A1  - Rudel, T.
A1  - Shi, Y.
A1  - Simon, H. U.
A1  - Stockwell, B. R.
A1  - Szabadkai, G.
A1  - Tait, S. W.
A1  - Tang, H. L.
A1  - Tavernarakis, N.
A1  - Tsujimoto, Y.
A1  - Vanden Berghe, T.
A1  - Vandenabeele, P.
A1  - Villunger, A.
A1  - Wagner, E. F.
A1  - Walczak, H.
A1  - White, E.
A1  - Wood, W. G.
A1  - Yuan, J.
A1  - Zakeri, Z.
A1  - Zhivotovsky, B.
A1  - Melino, G.
A1  - Kroemer, G.
T1  - Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
JF  - Cell Death and Differentiation
N2  - Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as 'accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. 'Regulated cell death' (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-121207
VL  - 22
ER  - 
TY  - JOUR
A1  - Pillai, Deepu R.
A1  - Heidemann, Robin M.
A1  - Kumar, Praveen
A1  - Shanbhag, Nagesh
A1  - Lanz, Titus
A1  - Dittmar, Michael S.
A1  - Sandner, Beatrice
A1  - Beier, Christoph P.
A1  - Weidner, Norbert
A1  - Greenlee, Mark W.
A1  - Schuierer, Gerhard
A1  - Bogdahn, Ulrich
A1  - Schlachetzki, Felix
T1  - Comprehensive Small Animal Imaging Strategies on a Clinical 3 T Dedicated Head MR-Scanner; Adapted Methods and Sequence Protocols in CNS Pathologies
JF  - PLoS ONE
N2  - Background: 

Small animal models of human diseases are an indispensable aspect of pre-clinical research. Being dynamic, most pathologies demand extensive longitudinal monitoring to understand disease mechanisms, drug efficacy and side effects. These considerations often demand the concomitant development of monitoring systems with sufficient temporal and spatial resolution. 

Methodology and Results: 

This study attempts to configure and optimize a clinical 3 Tesla magnetic resonance scanner to facilitate imaging of small animal central nervous system pathologies. The hardware of the scanner was complemented by a custom-built, 4-channel phased array coil system. Extensive modification of standard sequence protocols was carried out based on tissue relaxometric calculations. Proton density differences between the gray and white matter of the rodent spinal cord along with transverse relaxation due to magnetic susceptibility differences at the cortex and striatum of both rats and mice demonstrated statistically significant differences. The employed parallel imaging reconstruction algorithms had distinct properties dependent on the sequence type and in the presence of the contrast agent. The attempt to morphologically phenotype a normal healthy rat brain in multiple planes delineated a number of anatomical regions, and all the clinically relevant sequels following acute cerebral ischemia could be adequately characterized. Changes in blood-brain-barrier permeability following ischemia-reperfusion were also apparent at a later time. Typical characteristics of intracerebral haemorrhage at acute and chronic stages were also visualized up to one month. Two models of rodent spinal cord injury were adequately characterized and closely mimicked the results of histological studies. In the employed rodent animal handling system a mouse model of glioblastoma was also studied with unequivocal results. 

Conclusions: 

The implemented customizations including extensive sequence protocol modifications resulted in images of high diagnostic quality. These results prove that lack of dedicated animal scanners shouldn't discourage conventional small animal imaging studies.
KW  - Rat spinal-cord
KW  - Middle cerebral-artery
KW  - Blood-brain-barrier
KW  - Experimental intracerebral hemorrhage
KW  - Partially parallel acquisitions
KW  - Magnetic-resonance microscopy
KW  - IN-VIVO
KW  - Mouse-brain
KW  - Edema formation
KW  - White-matter
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-134193
VL  - 6
IS  - 2
ER  - 
TY  - JOUR
A1  - Levitis, Elizabeth
A1  - Gould van Praag, Cassandra D
A1  - Gau, Rémi
A1  - Heunis, Stephan
A1  - DuPre, Elizabeth
A1  - Kiar, Gregory
A1  - Bottenhorn, Katherine L
A1  - Glatard, Tristan
A1  - Nikolaidis, Aki
A1  - Whitaker, Kirstie Jane
A1  - Mancini, Matteo
A1  - Niso, Guiomar
A1  - Afyouni, Soroosh
A1  - Alonso-Ortiz, Eva
A1  - Appelhoff, Stefan
A1  - Arnatkeviciute, Aurina
A1  - Atay, Selim Melvin
A1  - Auer, Tibor
A1  - Baracchini, Giulia
A1  - Bayer, Johanna M M
A1  - Beauvais, Michael J S
A1  - Bijsterbosch, Janine D
A1  - Bilgin, Isil P
A1  - Bollmann, Saskia
A1  - Bollmann, Steffen
A1  - Botvinik-Nezer, Rotem
A1  - Bright, Molly G
A1  - Calhoun, Vince D
A1  - Chen, Xiao
A1  - Chopra, Sidhant
A1  - Chuan-Peng, Hu
A1  - Close, Thomas G
A1  - Cookson, Savannah L
A1  - Craddock, R Cameron
A1  - De La Vega, Alejandro
A1  - De Leener, Benjamin
A1  - Demeter, Damion V
A1  - Di Maio, Paola
A1  - Dickie, Erin W
A1  - Eickhoff, Simon B
A1  - Esteban, Oscar
A1  - Finc, Karolina
A1  - Frigo, Matteo
A1  - Ganesan, Saampras
A1  - Ganz, Melanie
A1  - Garner, Kelly G
A1  - Garza-Villarreal, Eduardo A
A1  - Gonzalez-Escamilla, Gabriel
A1  - Goswami, Rohit
A1  - Griffiths, John D
A1  - Grootswagers, Tijl
A1  - Guay, Samuel
A1  - Guest, Olivia
A1  - Handwerker, Daniel A
A1  - Herholz, Peer
A1  - Heuer, Katja
A1  - Huijser, Dorien C
A1  - Iacovella, Vittorio
A1  - Joseph, Michael J E
A1  - Karakuzu, Agah
A1  - Keator, David B
A1  - Kobeleva, Xenia
A1  - Kumar, Manoj
A1  - Laird, Angela R
A1  - Larson-Prior, Linda J
A1  - Lautarescu, Alexandra
A1  - Lazari, Alberto
A1  - Legarreta, Jon Haitz
A1  - Li, Xue-Ying
A1  - Lv, Jinglei
A1  - Mansour L., Sina
A1  - Meunier, David
A1  - Moraczewski, Dustin
A1  - Nandi, Tulika
A1  - Nastase, Samuel A
A1  - Nau, Matthias
A1  - Noble, Stephanie
A1  - Norgaard, Martin
A1  - Obungoloch, Johnes
A1  - Oostenveld, Robert
A1  - Orchard, Edwina R
A1  - Pinho, Ana Luísa
A1  - Poldrack, Russell A
A1  - Qiu, Anqi
A1  - Raamana, Pradeep Reddy
A1  - Rokem, Ariel
A1  - Rutherford, Saige
A1  - Sharan, Malvika
A1  - Shaw, Thomas B
A1  - Syeda, Warda T
A1  - Testerman, Meghan M
A1  - Toro, Roberto
A1  - Valk, Sofie L
A1  - Van Den Bossche, Sofie
A1  - Varoquaux, Gaël
A1  - Váša, František
A1  - Veldsman, Michele
A1  - Vohryzek, Jakub
A1  - Wagner, Adina S
A1  - Walsh, Reubs J
A1  - White, Tonya
A1  - Wong, Fu-Te
A1  - Xie, Xihe
A1  - Yan, Chao-Gan
A1  - Yang, Yu-Fang
A1  - Yee, Yohan
A1  - Zanitti, Gaston E
A1  - Van Gulick, Ana E
A1  - Duff, Eugene
A1  - Maumet, Camille
T1  - Centering inclusivity in the design of online conferences—An OHBM–Open Science perspective
JF  - GigaScience
N2  - As the global health crisis unfolded, many academic conferences moved online in 2020. This move has been hailed as a positive step towards inclusivity in its attenuation of economic, physical, and legal barriers and effectively enabled many individuals from groups that have traditionally been underrepresented to join and participate. A number of studies have outlined how moving online made it possible to gather a more global community and has increased opportunities for individuals with various constraints, e.g., caregiving responsibilities.

Yet, the mere existence of online conferences is no guarantee that everyone can attend and participate meaningfully. In fact, many elements of an online conference are still significant barriers to truly diverse participation: the tools used can be inaccessible for some individuals; the scheduling choices can favour some geographical locations; the set-up of the conference can provide more visibility to well-established researchers and reduce opportunities for early-career researchers. While acknowledging the benefits of an online setting, especially for individuals who have traditionally been underrepresented or excluded, we recognize that fostering social justice requires inclusivity to actively be centered in every aspect of online conference design.

Here, we draw from the literature and from our own experiences to identify practices that purposefully encourage a diverse community to attend, participate in, and lead online conferences. Reflecting on how to design more inclusive online events is especially important as multiple scientific organizations have announced that they will continue offering an online version of their event when in-person conferences can resume.
KW  - online conferences
KW  - diversity
KW  - inclusivity
KW  - open science
KW  - collaborative events
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-371574
VL  - 10
ER  -