TY  - THES
A1  - Schießer, Lena
T1  - Langzeitergebnisse nach Ross-Prozedur : Eine retrospektive Analyse
T1  - Long-term results after ross procedure : A retrospective analysis
N2  - 172 Patienten, welche von 06/17 bis 01/18 am Uniklinikum Würzburg entsprechend der Ross-Prozedur operiert wurden, wurden nachuntersucht (Follow Up: 6,2 ± 4,5 Jahre).
Ziel war es den Einfluss der Operationstechniken - Subkoronar (SK)- und Wurzelersatztechnik (WE) zu untersuchen sowie den Einfluss der Spenderklappen - Homograft (HG) und Matrixprothese (M).
Die Überlebensrate betrug in der SK- und WE-Gruppe jew. 98,1 %. Die Reoperationsrate lag bei 6,8 % (SK) und 3,9 % (WE). Bezüglich der postop. Hämodynamik wurden Normwerte ermittelt (SK und WE). NYHA Stadium I lag bei 74,1 % (SK) und 95,5 % (WE) vor. 

Bzgl. Überlebensrate (HG: 98,1 %; M: 95,4 %) sowie Reop.rationsrate (HG: 0 %; M: 33 %), postop. hämodyn. Werten und postop. klinischem Verlauf (NYHA Stadium I: 80 % der HG Gruppe, 50 % der M-Gruppe) schnitt die M-Gruppe schlechter ab.
N2  - There was a follow up of 172 patients which were operated according to the ross-procedure from 06/17 to 01/18.
The aim of the study was to analyze the impact of the surgical techniques - subcoronar (SC)- and the root replacement (RR) technique - and the impact of the donor flaps - homograft (hg) and matrixprothesis (m).
The survival rate was 98,1 % (SC and RR). The reoperation rate was 6,8 % (SC) and 3,9 % (RR) and there were normal values for the postop. hemodynamics. 74,1 % (SC) and 95,5 % (RR) were in NYHA Class I.
With reference to the survival rate (hg: 98,1 %; m: 95,4 %) as well as to the postop. hemodynamics and NYHA Class (hg: 80 %, m: 50 % Class I) the results for m-group were worse.
KW  - Ross-Prozedur
KW  - Ross-procedure
KW  - Aortenklappenersatz
KW  - Homograft
KW  - Matrixprothese
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-278382
ER  - 
TY  - JOUR
A1  - Stangl, Stephanie
A1  - Popp, Maria
A1  - Reis, Stefanie
A1  - Sitter, Magdalena
A1  - Saal-Bauernschubert, Lena
A1  - Schießer, Selina
A1  - Kranke, Peter
A1  - Choorapoikayil, Suma
A1  - Weibel, Stephanie
A1  - Meybohm, Patrick
T1  - Reported outcomes in patients with iron deficiency or iron deficiency anemia undergoing major surgery: a systematic review of outcomes
JF  - Systematic Reviews
N2  - Background
Iron deficiency (ID) is the leading cause of anemia worldwide. The prevalence of preoperative ID ranges from 23 to 33%. Preoperative anemia is associated with worse outcomes, making it important to diagnose and treat ID before elective surgery. Several studies indicated the effectiveness of intravenous iron supplementation in iron deficiency with or without anemia (ID(A)). However, it remains challenging to establish reliable evidence due to heterogeneity in utilized study outcomes. The development of a core outcome set (COS) can help to reduce this heterogeneity by proposing a minimal set of meaningful and standardized outcomes. The aim of our systematic review was to identify and assess outcomes reported in randomized controlled trials (RCTs) and observational studies investigating iron supplementation in iron-deficient patients with or without anemia.

Methods
We searched MEDLINE, CENTRAL, and ClinicalTrials.gov systematically from 2000 to April 1, 2022. RCTs and observational studies investigating iron supplementation in patients with a preoperative diagnosis of ID(A), were included. Study characteristics and reported outcomes were extracted. Outcomes were categorized according to an established outcome taxonomy. Quality of outcome reporting was assessed with a pre-specified tool. Reported clinically relevant differences for sample size calculation were extracted.

Results
Out of 2898 records, 346 underwent full-text screening and 13 studies (five RCTs, eight observational studies) with sufficient diagnostic inclusion criteria for iron deficiency with or without anemia (ID(A)) were eligible. It is noteworthy to mention that 49 studies were excluded due to no confirmed diagnosis of ID(A). Overall, 111 outcomes were structured into five core areas including nine domains. Most studies (92%) reported outcomes within the ‘blood and lymphatic system’ domain, followed by “adverse event” (77%) and “need for further resources” (77%). All of the latter reported on the need for blood transfusion. Reported outcomes were heterogeneous in measures and timing. Merely, two (33%) of six prospective studies were registered prospectively of which one (17%) showed no signs of selective outcome reporting.

Conclusion
This systematic review comprehensively depicts the heterogeneity of reported outcomes in studies investigating iron supplementation in ID(A) patients regarding exact definitions and timing. Our analysis provides a systematic base for consenting to a minimal COS.

Systematic review registration
PROSPERO CRD42020214247
KW  - iron deficiency
KW  - iron deficiency anemia
KW  - core outcome set
KW  - outcome reporting
KW  - data harmonization
KW  - preoperative setting
KW  - perioperative setting
KW  - surgery
Y1  - 2024
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-357213
VL  - 13
ER  -