TY  - JOUR
A1  - Salgarella, Alice Rita
A1  - Zahoranová, Anna
A1  - Šrámková, Petra
A1  - Majerčíková, Monika
A1  - Pavlova, Ewa
A1  - Luxenhofer, Robert
A1  - Kronek, Juraj
A1  - Lacík, Igor
A1  - Ricotti, Leonardo
T1  - Investigation of drug release modulation from poly(2-oxazoline) micelles through ultrasound
JF  - Scientific Reports
N2  - Among external stimuli used to trigger release of a drug from a polymeric carrier, ultrasound has gained increasing attention due to its non-invasive nature, safety and low cost. Despite this attention, there is only limited knowledge about how materials available for the preparation of drug carriers respond to ultrasound. This study investigates the effect of ultrasound on the release of a hydrophobic drug, dexamethasone, from poly(2-oxazoline)-based micelles. Spontaneous and ultrasound-mediated release of dexamethasone from five types of micelles made of poly(2-oxazoline) block copolymers, composed of hydrophilic poly(2-methyl-2-oxazoline) and hydrophobic poly(2-n-propyl-2-oxazoline) or poly(2-butyl-2-oxazoline-co-2-(3-butenyl)-2-oxazoline), was studied. The release profiles were fitted by zeroorder and Ritger-Peppas models. The ultrasound increased the amount of released dexamethasone by 6% to 105% depending on the type of copolymer, the amount of loaded dexamethasone, and the stimulation time point. This study investigates for the first time the interaction between different poly(2-oxazoline)-based micelle formulations and ultrasound waves, quantifying the efficacy of such stimulation in modulating dexamethasone release from these nanocarriers.
KW  - Acoustics
KW  - Biomedical engineering
KW  - Drug delivery
KW  - Materials chemistry
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227277
VL  - 8
ER  -