TY  - JOUR
A1  - Benoit, Sandrine
A1  - Scheurlen, Michael
A1  - Goebeler, Matthias
A1  - Stoevesandt, Johanna
T1  - Structured diagnostic approach and risk assessment in mucous membrane pemphigoid with oesophageal involvement
JF  - Acta Dermato-Venereologica
N2  - Oesophageal involvement in mucous membrane pemphigoid is considered rare, but it may be underdiagnosed. To assess the incidence of oesophageal involvement in a group of patients with newly diagnosed mucous membrane pemphigoid we retrospectively analysed the medical records of 30 consecutive patients with mucous membrane pemphigoid diagnosed between 2006 and 2016 at the Department of Dermatology, University Hospital Würzburg. Twenty-one patients (70%) reported symptoms indicative of oesophageal mucous membrane pemphigoid. Twelve patients (40%) underwent oesophagogastroduodenoscopy, and oesophageal pathology compatible with mucous membrane pemphigoid was endoscopically found in 9 cases (30%). In all patients indirect and direct immunofluorescence were performed. Patients with and without oesophageal involvement did not differ with regard to the results of indirect immunofluorescence on salt-split human skin and monkey oesophagus. Study results demonstrate the necessity of a standardized diagnostic work-up, including adequate tissue samples for direct immunofluorescence, to prevent underdiagnosis of oesophageal mucous membrane pemphigoid.
KW  - cicatricial pemphigoid
KW  - mucous membrane pemphigoid
KW  - oesophagogastroduodenoscopy
KW  - laminin 332
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-176191
VL  - 98
ER  -