TY  - JOUR
A1  - Grammatikos, Georgios
A1  - Lange, Christian
A1  - Susser, Simon
A1  - Schwendy, Susanne
A1  - Dikopoulos, Nektarios
A1  - Buggisch, Peter
A1  - Encke, Jens
A1  - Teuber, Gerlinde
A1  - Goeser, Tobias
A1  - Thimme, Robert
A1  - Klinker, Hartwig
A1  - Boecher, Wulf O.
A1  - Schulte-Frohlinde, Ewert
A1  - Penna-Martinez, Marissa
A1  - Badenhoop, Klaus
A1  - Zeuzem, Stefan
A1  - Berg, Thomas
A1  - Sarrazin, Christoph
T1  - Vitamin D Levels Vary during Antiviral Treatment but Are Unable to Predict Treatment Outcome in HCV Genotype 1 Infected Patients
JF  - PLOS ONE
N2  - Background: Different parameters have been determined for prediction of treatment outcome in hepatitis c virus genotype 1 infected patients undergoing pegylated interferon, ribavirin combination therapy. Results on the importance of vitamin D levels are conflicting. In the present study, a comprehensive analysis of vitamin D levels before and during therapy together with single nucleotide polymorphisms involved in vitamin D metabolism in the context of other known treatment predictors has been performed. 
Methods: In a well characterized prospective cohort of 398 genotype 1 infected patients treated with pegylated interferon-alpha and ribavirin for 24-72 weeks (INDIV-2 study) 25-OH-vitamin D levels and different single nucleotide polymorphisms were analyzed together with known biochemical parameters for a correlation with virologic treatment outcome. 
Results: Fluctuations of more than 5 (10) ng/ml in 25-OH-vitamin D-levels have been observed in 66 (39) % of patients during the course of antiviral therapy and neither pretreatment nor under treatment 25-OH-vitamin D-levels were associated with treatment outcome. The DHCR7-TT-polymorphism within the 7-dehydrocholesterol-reductase showed a significant association (P = 0.031) to sustained viral response in univariate analysis. Among numerous further parameters analyzed we found that age (OR = 1.028, CI = 1.002-1.056, P = 0.035), cholesterol (OR = 0.983, CI = 0.975-0.991, P<0.001), ferritin (OR = 1.002, CI = 1.000-1.004, P = 0.033), gGT (OR = 1.467, CI = 1.073-2.006, P = 0.016) and IL28B-genotype (OR = 2.442, CI = 1.271-4.695, P = 0.007) constituted the strongest predictors of treatment response. 
Conclusions: While 25-OH-vitamin D-levels levels show considerable variations during the long-lasting course of antiviral therapy they do not show any significant association to treatment outcome in genotype 1 infected patients.
KW  - chronic Hepatitis C
KW  - sustained virological response
KW  - common genetic determinants
KW  - D serum-levels
KW  - IL28B polymorphisms
KW  - interferon alpha
KW  - viral clearance
KW  - virus infection
KW  - severe fibrosis
KW  - D insufficiency
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-117310
SN  - 1932-6203
VL  - 9
IS  - 2
ER  -