TY  - JOUR
A1  - Hibar, Derrek P.
A1  - Adams, Hieab H.H.
A1  - Jahanshad, Neda
A1  - Chauhan, Ganesh
A1  - Stein, Jason L
A1  - Hofer, Edith
A1  - Renteria, Miguel E.
A1  - Bis, Joshua C.
A1  - Arias-Vasquez, Alejandro
A1  - Ikram, M. Kamran
A1  - Desrivières, Sylvane
A1  - Vernooij, Meike W.
A1  - Abramovic, Lucija
A1  - Alhusaini, Saud
A1  - Amin, Najaf
A1  - Andersson, Micael
A1  - Arfanakis, Konstantinos
A1  - Aribisala, Benjamin S.
A1  - Armstrong, Nicola J.
A1  - Athanasiu, Lavinia
A1  - Axelsson, Tomas
A1  - Beecham, Ashley H.
A1  - Beiser, Alexa
A1  - Bernard, Manon
A1  - Blanton, Susan H.
A1  - Bohlken, Marc M.
A1  - Boks, Marco P.
A1  - Bralten, Janita
A1  - Brickman, Adam M.
A1  - Carmichael, Owen
T1  - Novel genetic loci associated with hippocampal volume
JF  - Nature Communications
N2  - The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer’s disease (r\(_g\)=−0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
KW  - brain
KW  - hippocampal formation
KW  - neuropsychiatric disorders
KW  - Alzheimer’s disease
KW  - genetic loci
KW  - hippocampal volume
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-182115
VL  - 8
ER  - 
TY  - JOUR
A1  - Rauch, Bernhard
A1  - Salzwedel, Annett
A1  - Bjarnason-Wehrens, Birna
A1  - Albus, Christian
A1  - Meng, Karin
A1  - Schmid, Jean-Paul
A1  - Benzer, Werner
A1  - Hackbusch, Matthes
A1  - Jensen, Katrin
A1  - Schwaab, Bernhard
A1  - Altenberger, Johann
A1  - Benjamin, Nicola
A1  - Bestehorn, Kurt
A1  - Bongarth, Christa
A1  - Dörr, Gesine
A1  - Eichler, Sarah
A1  - Einwang, Hans-Peter
A1  - Falk, Johannes
A1  - Glatz, Johannes
A1  - Gielen, Stephan
A1  - Grilli, Maurizio
A1  - Grünig, Ekkehard
A1  - Guha, Manju
A1  - Hermann, Matthias
A1  - Hoberg, Eike
A1  - Höfer, Stefan
A1  - Kaemmerer, Harald
A1  - Ladwig, Karl-Heinz
A1  - Mayer-Berger, Wolfgang
A1  - Metzendorf, Maria-Inti
A1  - Nebel, Roland
A1  - Neidenbach, Rhoia Clara
A1  - Niebauer, Josef
A1  - Nixdorff, Uwe
A1  - Oberhoffer, Renate
A1  - Reibis, Rona
A1  - Reiss, Nils
A1  - Saure, Daniel
A1  - Schlitt, Axel
A1  - Völler, Heinz
A1  - Känel, Roland von
A1  - Weinbrenner, Susanne
A1  - Westphal, Ronja
T1  - Cardiac rehabilitation in German speaking countries of Europe — evidence-based guidelines from Germany, Austria and Switzerland LLKardReha-DACH — Part 1
JF  - Journal of Clinical Medicine
N2  - Background: Although cardiovascular rehabilitation (CR) is well accepted in general, CR-attendance and delivery still considerably vary between the European countries. Moreover, clinical and prognostic effects of CR are not well established for a variety of cardiovascular diseases. Methods: The guidelines address all aspects of CR including indications, contents and delivery. By processing the guidelines, every step was externally supervised and moderated by independent members of the “Association of the Scientific Medical Societies in Germany” (AWMF). Four meta-analyses were performed to evaluate the prognostic effect of CR after acute coronary syndrome (ACS), after coronary bypass grafting (CABG), in patients with severe chronic systolic heart failure (HFrEF), and to define the effect of psychological interventions during CR. All other indications for CR-delivery were based on a predefined semi-structured literature search and recommendations were established by a formal consenting process including all medical societies involved in guideline generation. Results: Multidisciplinary CR is associated with a significant reduction in all-cause mortality in patients after ACS and after CABG, whereas HFrEF-patients (left ventricular ejection fraction <40%) especially benefit in terms of exercise capacity and health-related quality of life. Patients with other cardiovascular diseases also benefit from CR-participation, but the scientific evidence is less clear. There is increasing evidence that the beneficial effect of CR strongly depends on “treatment intensity” including medical supervision, treatment of cardiovascular risk factors, information and education, and a minimum of individually adapted exercise volume. Additional psychologic interventions should be performed on the basis of individual needs. Conclusions: These guidelines reinforce the substantial benefit of CR in specific clinical indications, but also describe remaining deficits in CR-delivery in clinical practice as well as in CR-science with respect to methodology and presentation.
KW  - cardiac rehabilitation standards
KW  - scientific guidelines
KW  - secondary prevention
KW  - coronary artery disease
KW  - chronic heart failure
KW  - heart valve repair
KW  - ICD-CRT
KW  - ventricular assist device
KW  - heart transplantation
KW  - peripheral artery disease
KW  - pulmonary hypertension
KW  - myocarditis
KW  - adults with congenital heart disease
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-239709
SN  - 2077-0383
VL  - 10
IS  - 10
ER  -